Leukocyte Ig-Like Receptor A3/LILRA3/ILT6/CD85e (C-Fc) (recombinant human)

Protein Construction: Recombinant Human Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 3 is produced by our Mammalian expression system and the target gene encoding Gly24-Glu439 is expressed with a Fc tag at the C-terminus. Sequence: Gly24-Glu439. Fusion tag: C-Fc Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 84-98 kDa. Protein function: Leukocyte immunoglobulin-like receptor subfamily A member 3 is also known as CD85 antigen-like family member E, Immunoglobulin-like transcript 6, ILT-6, Leukocyte immunoglobulin-like receptor 4, LIR-4 and Monocyte inhibitory receptor HM43/HM31. In humans, it is encoded by the LILRA3 gene. It acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2.It is detected in B-cells, natural killer (NK) cells, peripheral blood monocytes and lung. Protein function: Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes. [The UniProt Consortium]