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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
373983.20 | 20 µg | - | - |
3 - 19 business days* |
575.00€
|
||
373983.100 | 100 µg | - | - |
3 - 19 business days* |
855.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a... more
Product information "LAMTOR1, Recombinant, Human, aa1-161, His-Tag (Ragulator Complex Protein LAMTOR1)"
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation. Source: Recombinant protein corresponding to aa1-161 from human LAMTOR1, fused to His-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~21.7kD, AA Sequence: MGCCYSSENEDSDQDREERKLLLDPSSPPTKALNGAEPNYHSLPSARTDEQALLSSILAKTASNIIDVSAADSQGMEQHEYMDRARQYSTRLAVLSSSLTHWKKLPPLPSLTSQPHQVLASEPIPFSDLQQVSRIAAYAYSALSQIRVDAKEELVVQFGIP, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | PP7157, LAMTOR1, C11orf59, p27RF-Rho, Lipid raft adaptor protein p18, Ragulator complex protein LAMTOR1, p27Kip1-releasing factor from RhoA, Protein associated with DRMs and endosomes, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1 |
Supplier: | United States Biological |
Supplier-Nr: | 373983 |
Properties
Conjugate: | No |
MW: | 21,7 |
Format: | Highly Purified |
Database Information
KEGG ID : | K20397 | Matching products |
UniProt ID : | Q6IAA8 | Matching products |
Gene ID | GeneID 55004 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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