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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay32019-100 | 100 µg | - |
6 - 10 business days* |
439.00€
|
|||
Cay32019-1 | 1 mg | - |
6 - 10 business days* |
2,852.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Leukocyte-associated immunoglobulin-like receptor 2 (LAIR-2) is a soluble homolog of the... more
Product information "LAIR-2 (human, recombinant)"
Leukocyte-associated immunoglobulin-like receptor 2 (LAIR-2) is a soluble homolog of the membrane-bound inhibitory immune receptor LAIR-1. LAIR-2, which is comprised of a single immunoglobulin-like domain, binds to collagen and inhibits the LAIR-1/collagen interaction and subsequent activation of immunocytes. It is produced by human peripheral blood mononuclear cells (PBMCs), monocytic and T cell lines, and activated CD4+ T cells. LAIR-2 fused to the Fc region of human IgG1 inhibits collagen-induced platelet aggregation, adhesion of platelets to collagen-coated coverslips, and binding of collagen to von Willebrand factor (VWF) and glycoprotein VI (GpVI). Elevated levels of LAIR-2 have been found in the urine of pregnant women, the synovial fluid of patients with rheumatoid arthritis, and sera from patients with autoimmune thyroid diseases. Cayman's LAIR-2 (human, recombinant) protein can be used for binding assay applications. This protein consists of 131 amino acids, has a calculated molecular weight of 14.1 kDa, and a predicted N-terminus of Gln22 after signal peptide cleavage. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is 22 kDa due to glycosylation.Synonyms: CD306, Leukocyte-associated Immunoglobulin-like Receptor 2. Purity: >93% estimated by SDS-PAGE. Endotoxin Testing: <1.0 EU/µg, determined by the LAL endotoxin assay. Source: Active recombinant human LAIR-2 expressed in HEK293 cells. Amino Acids: 22-152. MW: 14.1 kDa. Formulation: (Request formulation change), Lyophilized from sterile 50 mM Tris with 0.7 M sodium chloride, pH 8.0.
Keywords: | CD306, Leukocyte-associated Immunoglobulin-like Receptor 2 |
Supplier: | Cayman Chemical |
Supplier-Nr: | 32019 |
Properties
Application: | Active protein |
Conjugate: | No |
Host: | Human cells |
Species reactivity: | human |
MW: | 14.1 kD |
Purity: | >93% estimated by SDS-PAGE |
Format: | Lyophilized |
Database Information
KEGG ID : | K06725 | Matching products |
UniProt ID : | Q6ISS4 | Matching products |
Gene ID | GeneID 3904 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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