LAG3 / CD223 / Lymphocyte activation gene 3 Protein (His tag) (recombinant rat)

Protein Construction: A DNA sequence encoding the rat LAG3 (Q5BK54)(Met1-Leu442) was expressed with a polyhistidine tag at the C-terminus. Sequence: Met1-Leu442. Fusion tag: C-His Endotoxin: < 1.0 EU per µg of the protein as determined by the LAL method Apparent Molecular Mass: 55 kDa. Protein function: LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells. It also acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signalling, leading to increased antigen-specific T-cell responses in vivo.Immune CheckpointImmune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets Immunotherapy   Cancer Immunotherapy   Targeted Therapy Protein function: Involved in lymphocyte activation. Binds to HLA class-II antigens. [The UniProt Consortium]