KLK2, Recombinant, Human (Kallikrein-2, Glandular Kallikrein-1, hGK-1, Tissue Kallikrein-2, Kallikre

Kallikrein 2 (KLK2) is a secreted serine protease that is highly expressed in the human prostate gland. It is also known as the prostate­specific glandular kallikrein. The enzyme is highly specific for cleavage after arginine residues. KLK2 is able to activate the urokinase­type plasminogen activator. KLK2 is inhibited by serpins such as protein C inhibitor, antichymotrypsin, and plasminogen activator inhibitor 1. KLK2 is structurally related to KLK3, the prostate­specific antigen (PSA). Like PSA, KLK2 is considered to be a biomarker for prostate cancer. Source: Murine myeloma cell line, NS0-derived Met1­-Pro261, with a C-­terminal 10­His tag. SDS-PAGE: 34kD & 15-18kD, reducing conditions, Activity: Measured by its ability to cleave a flourogenic peptide substrate Pro-Phe-Arg-7-amido-4-methylcoumarin (PFR-AMC). Specific Activity: >125pmoles/min/ug. Endotoxin Level: <1EU/1ug (LAL) , Storage and Stability:, For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 12 months.