ICAM-1/CD54 protein (Fc tag), recombinant rat

Activity: Testing in progress Protein Construction: A DNA sequence encoding the Rat ICAM-1 protein (Q00238) (Met1-Thr493) was expressed with a C-Fc. Sequence: Met1-Thr493. Fusion tag: C-hFc Endotoxin: Please contact us for more information. Apparent Molecular Mass: 90 kDa. Protein function: Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on e Protein function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. [The UniProt Consortium]