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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-PKSH031681.50 | 50 µg | - |
7 - 16 business days* |
1,025.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein Construction: A DNA sequence encoding the human HGF activator precursor (NP_001519.1)... more
Product information "HGFA Protein (His tag) (recombinant human)"
Protein Construction: A DNA sequence encoding the human HGF activator precursor (NP_001519.1) (Met 1-Ser 655) was expressed with a fused polyhistidine-tag at the C-terminus. Sequence: Met 1-Ser 655. Fusion tag: C-His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 34, 37, 65, 105 kDa. Protein function: HGF activator (HGFA) is a serum-derived serine protease and belongs to the peptidase family S1.HGFA is responsible for the conversion of hepatocyte growth factor (HGF), from the inactive single-chain precursor to the active heterodimeric form, which is a potent mitogen, motogen, and morphogen for liver cells, epithelial cells, and endothelial cells. HGFA is synthesized and secreted by the liver and circulates in the plasma as an inactive single-chain zymogen in normal states. The zymogen is cleaved by thrombin or thermolysin through the endoproteolytic process and forms an active heterodimer linked by a disulfide bond. In turn, the active protease can be inhibited by HGFA inhibitors (HAIs) including HAI-1 and HAI-2. In addition, the HGFA zymogen acquires a strong affinity upon activation and thus may ensure the local action in tissue regeneration in liver, kidney and skin. It has been reported that activation of HGF is a critical limiting step in the HGF/SF-induced signaling pathway mediated by Met, and acco Protein function: Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form. [The UniProt Consortium]
Keywords: | HGFAC, EC=3.4.21.-, Recombinant Human HGFA Protein (His tag) |
Supplier: | Elabscience |
Supplier-Nr: | E-PKSH031681 |
Properties
Conjugate: | No |
Host: | Human cells |
Species reactivity: | human |
MW: | 68.2 kD |
Format: | Lyophilized |
Database Information
KEGG ID : | K09631 | Matching products |
UniProt ID : | Q04756 | Matching products |
Gene ID | GeneID 3083 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | +4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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