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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay31037-100 | 100 µg | - |
6 - 10 business days* |
514.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Glutaredoxin 1 (Grx1) is a thiol-disulfide oxidoreductase and member of the thioredoxin family... more
Product information "Glutaredoxin 1 (human, recombinant)"
Glutaredoxin 1 (Grx1) is a thiol-disulfide oxidoreductase and member of the thioredoxin family encoded by GLRX1 with a role in the maintenance of cellular thiol redox homeostasis. It is ubiquitously expressed and localizes to the cytosol, nucleus, and mitochondrial intermembrane space. Grx1 is a dithiol Grx that contains two active site cysteine residues, which catalyze the deglutathionylation of protein disulfides and glutathionylated proteins to regulate redox signal transduction and repair oxidized proteins. Knockdown or overexpression of GLRX1 enhances or reduces, respectively, oxidative stress-induced apoptosis in HEK293T cells. Glrx1-/- mice have increased bronchoalveolar lavage fluid (BALF) macrophage infiltration and lung glutathionylated protein levels induced by cigarette smoke compared with wild-type mice. Grx1 levels are decreased in postmortem brain from patients with Parkinson's disease. Cayman's Glutaredoxin 1 (human, recombinant) can be used for enzyme activity assays.Synonyms: Glrx1, Grx1, Thioltransferase 1, TTF1. Purity: >95% estimated by SDS-PAGE. Source: Active human recombinant N-terminal His-TEV tagged Grx1 expressed in E. coli. Amino Acids: 2-106. MW: 13.9 kDa. Formulation: (Request formulation change), 50 mM Tris-HCl, pH 7.8, with 150 mM sodium chloride, 10% glycerol, 1 mM EDTA, and 0.1 mM DTT. UniProt Accession #: P35754.
Keywords: | GRX, GLRX, TTase-1, TTase-1, Glutaredoxin-1, Glutaredoxin-1, Thioltransferase-1, Thioltransferase-1 |
Supplier: | Cayman Chemical |
Supplier-Nr: | 31037 |
Properties
Application: | Enzyme assays |
Conjugate: | No |
Species reactivity: | human |
Purity: | >95% estimated by SDS-PAGE |
Format: | Solution |
Database Information
KEGG ID : | K03676 | Matching products |
UniProt ID : | P35754 | Matching products |
Gene ID | GeneID 2745 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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