GITR/TNFRSF18 Protein (mFc Tag) (recombinant human)

Protein Construction: Recombinant human GITR is produced by our Mammalian expression system and the target gene encoding Gln26-Glu161(Thr45Ala) is expressed with a mFc tag at the C-terminus. Sequence: Gln26-Glu161(Thr45Ala). Fusion tag: C-mFc Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 40-55 kDa. Protein function: Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA?isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway.It binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6 and binds through its C-terminus to SIVA1/SIVA.It preferentially expressed in activated T lymphocytes and up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation. Protein function: Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. [The UniProt Consortium]