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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay33991-50 | 50 µg | - | - |
6 - 10 business days* |
439.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Cytosolic beta-glucosidase (GBA3) is a neutral beta-glucocerebrosidase. It is composed of a... more
Product information "GBA3 (human, recombinant)"
Cytosolic beta-glucosidase (GBA3) is a neutral beta-glucocerebrosidase. It is composed of a single glycoside hydrolase domain and hydrolyzes glucosyl- and galactosylceramides. GBA3 is expressed in the liver, small intestine, colon, spleen, and kidneys. In vitro, knockdown of GBA3 inhibits mitotic arrest and promotes resistance to paclitaxel (Cay-10461) in colon cancer cells. Tumor levels of GBA3 are lower in patients with hepatocellular carcinoma and decreased expression is associated with poor prognosis. Unlike GBA1, polymorphisms in GBA3 are not associated with Gaucher disease, a lysosomal storage disorder. Cayman's GBA3 (human, recombinant) protein can be used for enzyme activity assays. This protein consists of 480 amino acids and has a calculated molecular weight of 55 kDa.Synonyms: cBGL1, Cytosolic beta-Glucosidase, Cytosolic beta-Glucosidase-like Protein-1, Klotho-related Protein, KLrP. Purity: >90% estimated by SDS-PAGE. Endotoxin Testing: <1.0 EU/µg, determined by the LAL endotoxin assay. Source: Active recombinant human C-terminal His-tagged GBA3 expressed in insect cells. Amino Acids: 1-469 (full length). MW: 55 kDa. Formulation: (Request formulation change), Lyophilized from sterile 20 mM Tris, 300 mM sodium chloride, pH 7.5, with 10% glycerol, 5% trehalose, 5% mannitol, and 0.01% tween-80. Host: Insect cells. UniProt Accession #: Q9H227.
Keywords: | CBG, KLrP, KLrP, Cytosolic GCase, Cytosolic GCase, Klotho-related protein, Klotho-related protein, Glucosidase beta acid 3, Glucosidase beta acid 3, Glucosylceramidase beta 3, Glucosylceramidase beta 3, Cytosolic beta-glucosidase, Cytosolic beta-glucosida |
Supplier: | Cayman Chemical |
Supplier-Nr: | 33991 |
Properties
Application: | Active enzyme |
Conjugate: | No |
Host: | Insect cells |
Purity: | >90% estimated by SDS-PAGE |
Format: | Lyophilized |
Database Information
KEGG ID : | K05350 | Matching products |
UniProt ID : | Q9H227 | Matching products |
Gene ID | GeneID 57733 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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