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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Mouse recombinant LGALS1 produced E.coli is a single polypeptide chain containing 159 amino acids... more
Product information "Galectin-1, His tag, recombinant mouse (rmLGALS1-His)"
Mouse recombinant LGALS1 produced E.coli is a single polypeptide chain containing 159 amino acids (1-135) and having a molecular mass of 17kDa. LGALS1 is fused to a 24 amino acid His-tag at N-terminus. The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Galectin-1 is an autocrine negative growth factor that regulates cell proliferation. Galectin-1 regulates cell apoptosis and cell differentiation. Galectin-1 binds CD45, CD3 and CD4 and inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of lyn kinase. Galectin-1 and its ligands are one of the master regulators of immune responses as T-cell homeostasis and survival, T-cell immune disorders, inflammation and allergies as well as host-pathogen interactions. Galectin-1 expression or overexpression in tumors and/or the tissue surrounding them must be considered as a sign of the malignant tumor progression that is often related to the long-range dissemination of tumoral cells (metastasis), to their dissemination into the surrounding normal tissue, and to tumor immune-escape. Galectin-1 in its oxidized form plays a number of important roles in the regeneration of the central nervous system after injury. The targeted overexpression (or delivery) of Galectin-1 should be considered as a method of choice for the treatment of some kinds of inflammation-related diseases, neurodegenerative pathologies and muscular dystrophies. In contrast, the targeted inhibition of Galectin-1 expression is what should be developed for therapeutic applications against cancer progression. Galectin-1 is thus a promising molecular target for the development of new and original therapeutic tools. There is 88% homology between the human and mouse galectin-1.
Keywords: | Gbp, Gal-1, Lgals1, Galaptin, Galectin-1, 14 kDa lectin, S-Lac lectin 1, Lactose-binding lectin 1, Lectin galactoside-binding soluble 1, Beta-galactoside-binding lectin L-14-I |
Supplier: | Biomol GmbH |
Supplier-Nr: | 97605 |
Properties
Application: | Bioassays |
Conjugate: | No |
Host: | E.coli |
Species reactivity: | mouse |
MW: | 17000 D |
Purity: | >95% |
Format: | Solution |
Database Information
KEGG ID : | K06830 | Matching products |
UniProt ID : | P16045 | Matching products |
Gene ID | GeneID 16852 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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