G9a-like protein (human recombinant)

G9a-like protein (human recombinant)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10755-50 50 µg - -

1 - 10 business days

Post-translational modification of histones by methylation of lysine residues can promote... more
Product information "G9a-like protein (human recombinant)"
Post-translational modification of histones by methylation of lysine residues can promote transcriptional activation or repression. G9a-like protein (GLP) and G9a are SET domain-containing methyltransferases that specifically mono- and di-methylate histone H3 at lysine 9 (H3K9). Methylation of H3K9 by a GLP/G9a heteromeric complex regulates gene expression by silencing euchromatin. GLP and G9a share 80% sequence identity in their SET domains. Structure-activity relationship (SAR) studies have been employed to design potent and selective inhibitors of these proteins, including BIX-01294 and UNC0638, with IC50 values in the nanomolar range.
Keywords: Histone-lysine N-methyltransferase EHMT1, G9a-like protein 1, Histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, Lysine N-methyltransferase 1D, EC=
Supplier: Cayman Chemical
Supplier-Nr: 10755-50


Application: Enzyme activity
Conjugate: No
Expressed in: E.coli
MW: 60,3 kD
Purity: >95% estimated by SDS-PAGE

Database Information

KEGG ID : K11420 | Search using KEGG ID
UniProt ID : Q9H9B1 | Search using UniProt ID

Handling & Safety

Storage: -80°C
Shipping: -20°C (International: -80°C)
Our products are for laboratory research use only: Not for administration to humans!
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