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GLP SAM-Screener(TM) Assay Kit
GLP SAM-Screener(TM) Assay Kit

Item number: Cay600570-1920

Most histone lysine methyltransferases contain a conserved domain (SET) that utilizes S-adenosyl-L-methionine (SAM or AdoMet) as a co-factor to catalyze the methylation of the epsilon amino group of lysine. G9a-like protein (GLP) is a SET domain-containing methyltransferase that specifically mono- and di-methylates...
Keywords: GLP, GLP1, EHMT1, EUHMTASE1, Eu-HMTase1, EC=2.1.1.-, EC=2.1.1.43, H3-K9-HMTase 5, G9a-like protein 1, Lysine...
Application: Fluorescence, HTS
From 469.00€
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Anti-G9A/EHMT2 (IHC)
Anti-G9A/EHMT2 (IHC)

Item number: IHC-00489

Protein function: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of...
Keywords: Anti-BAT8, Anti-EHMT2, EC=2.1.1.-, EC=2.1.1.43, Anti-Protein G9a, Anti-H3-K9-HMTase 3, Anti-HLA-B-associated transcript 8,...
Application: IHC
Reactivity: Human
From 125.00€
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Anti-EHMT2 / G9A
Anti-EHMT2 / G9A

Item number: ARG55880.100

Protein function: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of...
Keywords: Anti-BAT8, Anti-EHMT2, EC=2.1.1.-, Anti-Protein G9a, EC=2.1.1.43, Anti-H3-K9-HMTase 3, Anti-HLA-B-associated transcript 8,...
Application: WB
Reactivity: Human, Mouse
452.00€
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BIX 01294
BIX 01294

Item number: AG-CR1-0051-M001

Selective and cell permeable G9a histone lysine methyltransferase (HMTase) inhibitor. Pluripotent stem cell inducer.
Keywords: 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]4-quinazolinamine
Application: HMTase inhibitor
CAS 935693-62-2
MW: 490,6 D
From 36.00€
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BIX 01294 . trihydrochloride
BIX 01294 . trihydrochloride

Item number: AG-CR1-0150-M001

Selective and cell permeable G9a histone lysine methyltransferase (HMTase) inhibitor. Does not compete with cofactor S-adenosylmethionine, Pluripotent stem cell inducer.
Keywords: 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]4-quinazolinamine . 3HCl
Application: HMTase inhibitor
CAS 935693-62-2
MW: 490,6 D
From 31.00€
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BRD4770
BRD4770

Item number: Cay11787-1

BRD4770 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, decreasing di- and trimethylation on lysine 9 of histone 3 (EC50 = 5 µM). Through its effects on EHMT2, BRD4770 induces senescence in the pancreatic cancer cell line PANC-1 without initiating apoptosis. It also blocks both...
Keywords: HMTase Inhibitor VI, 2-(benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylic acid, methyl ester
Application: EHMT2 inhibitor
CAS 1374601-40-7
MW: 413.5 D
From 32.00€
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UNC0224
UNC0224

Item number: Cay13631-1

The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development. UNC0224 is...
Keywords: 7-[3-(dimethylamino)propoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolin...
Application: G9a HMTase inhibitor
CAS 1197196-48-7
MW: 485.7 D
From 48.00€
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UNC0321 (trifluoroacetate salt)
UNC0321 (trifluoroacetate salt)

Item number: Cay10582-1

The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development. UNC0321 is...
Keywords: 7-(2-(2-(dimethylamino)ethoxy)ethoxy)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amin...
Application: G9a HMTase inhibitor
MW: 857.8 D
From 48.00€
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UNC0638
UNC0638

Item number: Cay10734-1

The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development. UNC0638 is...
Keywords: 2-cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine
Application: G9a HMTase inhibitor
CAS 1255580-76-7
MW: 509.7 D
From 48.00€
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UNC0646
UNC0646

Item number: Cay11085-1

G9a and G9a-like protein (GLP) are euchromatic histone-lysine methyltransferases (EHMT2 and EHMT1, respectively) that can heterodimerize with each other to methylate several proteins in addition to histone H3. UNC0646 is a potent and selective inhibitor of G9a and GLP activities in vitro (IC50s = 6 and 15 nM,...
Keywords: N-(1-cyclohexyl-4-piperidinyl)-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]...
Application: Potent, selective EHMT1 / EHMT2 inhibitor
CAS 1320288-17-2
MW: 621.9 D
From 48.00€
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BRD9539
BRD9539

Item number: Cay11788-1

BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, with an IC50 value of 6.3 µM. It inhibits polycomb repressive complex 2 (PRC2) to a similar extent with 54 and 43% activity remaining for G9a and PRC2, respectively, when used at a concentration of 10 µM. It is selective...
Keywords: 2-(benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylic acid
Application: G9a / PRC2 inhibitor
CAS 1374601-41-8
MW: 399.4 D
From 32.00€
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UNC0642
UNC0642

Item number: Cay14604-1

The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferases G9a and G9a-like protein (GLP) can mono- or dimethylate lysine 9 on histone 3, contributing to early embryogenesis, genomic imprinting, and lymphocyte...
Keywords: 2-(4,4-difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine
Application: EHMT1 / EHMT2 inhibitor
CAS 1481677-78-4
MW: 546.7 D
From 62.00€
Review
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