65 products were found matching "K11420"!

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UNC0638
UNC0638

Item number: Cay10734-1

The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development. UNC0638 is...
Keywords: 2-cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine
Application: G9a HMTase inhibitor
CAS 1255580-76-7
MW: 509.7 D
From 65.00€ *
Review
BIX01294 (hydrochloride hydrate)
BIX01294 (hydrochloride hydrate)

Item number: Cay13124-1

The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development. BIX01294...
Keywords: 2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine,...
Application: G9a HMTase inhibitor
CAS 1808255-64-2
MW: 600 D
From 40.00€ *
Review
A-366
A-366

Item number: Cay16081-5

A-366 is a potent, peptide-competitive inhibitor of the lysine methyltransferase G9a (IC50 = 3.3 nM). It displays greater than 1,000-fold selectivity over 21 other methyltransferases. A-366 significantly reduces the cellular levels of dimethylation on histone 3 at lysine 9 (H3K9Me2) in PC3 cells without reducing...
Keywords: 5'-methoxy-6'-[3-(1-pyrrolidinyl)propoxy]-spiro[cyclobutane-1,3'-[3H]indol]-2'-amine
Application: EHMT2 inhibitor
CAS 1527503-11-2
MW: 329.4 D
From 114.00€ *
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Anti-EHMT1
Anti-EHMT1

Item number: A301-642A

Protein function: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27'...
Keywords: Anti-GLP, Anti-GLP1, Anti-EHMT1, Anti-EUHMTASE1, EC=2.1.1.-, Anti-Eu-HMTase1, EC=2.1.1.43, Anti-H3-K9-HMTase 5,...
Application: WB, IP, IHC
Host: Rabbit
Species reactivity: human
From 164.00€ *
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-10 %
BIX 01294
BIX 01294

Item number: AG-CR1-0051-M001

Selective and cell permeable G9a histone lysine methyltransferase (HMTase) inhibitor. Pluripotent stem cell inducer.
Keywords: 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]4-quinazolinamine
Application: HMTase inhibitor
CAS 935693-62-2
MW: 490,6 D
36.00€ * From 32.40€ *
Review
UNC0224
UNC0224

Item number: Cay13631-5

The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development. UNC0224 is...
Keywords: 7-[3-(dimethylamino)propoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolin...
Application: G9a HMTase inhibitor
CAS 1197196-48-7
MW: 485.7 D
From 65.00€ *
Review
Anti-G9A/EHMT2
Anti-G9A/EHMT2

Item number: A300-933A

Protein function: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of...
Keywords: Anti-BAT8, Anti-EHMT2, EC=2.1.1.-, EC=2.1.1.43, Anti-Protein G9a, Anti-H3-K9-HMTase 3, Anti-HLA-B-associated transcript 8,...
Application: WB, IP, IHC
Host: Rabbit
Species reactivity: human
From 164.00€ *
Review
UNC0642
UNC0642

Item number: Cay14604-1

The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferases G9a and G9a-like protein (GLP) can mono- or dimethylate lysine 9 on histone 3, contributing to early embryogenesis, genomic imprinting, and lymphocyte...
Keywords: 2-(4,4-difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine
Application: EHMT1 / EHMT2 inhibitor
CAS 1481677-78-4
MW: 546.7 D
From 84.00€ *
Review
UNC0631
UNC0631

Item number: Cay11084-10

UNC0631 is a potent and selective inhibitor of G9a activity in vitro (IC50 = 4 nM) and G9a/GLP-mediated dimethylation of histone 3 on lysine 9 in MDA-MB-231 cells (IC50 = 25 nM). It potently inhibits G9a/GLP activity in a variety of cancer cell lines as well as in the human fetal lung IMR-90 cell line.Formal Name:...
Keywords: N-[1-(cyclohexylmethyl)-4-piperidinyl]-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)...
Application: Potent, selective EHMT1 / EHMT2 inhibitor
CAS 1320288-19-4
MW: 635.9 D
From 50.00€ *
Review
EHMT1 (GLP), human recombinant protein
EHMT1 (GLP), human recombinant protein

Item number: BPS-51020

Human euchromatic histone-lysine N-methyltransferase (EHMT1), also known as G9a-like protein (GLP) or KMT1D, GenBank Accession No. NM_024757, a.a. 894-1298 (end) with N-terminal GST-tag, MW= 72.4 kDa, expressed in an E. coli expression system.
Keywords: GLP, GLP1, EHMT1, EUHMTASE1, Eu-HMTase1, H3-K9-HMTase 5, G9a-like protein 1, Lysine N-methyltransferase 1D, Histone H3-K9...
Application: Enzyme kinetics, inhibitor screening, selectivity profiling
Expressed in: E.coli
Origin: human
MW: 72.4 kD
650.00€ *
Review
-10 %
BIX 01294 . trihydrochloride
BIX 01294 . trihydrochloride

Item number: AG-CR1-0150-M001

Selective and cell permeable G9a histone lysine methyltransferase (HMTase) inhibitor. Does not compete with cofactor S-adenosylmethionine, Pluripotent stem cell inducer.
Keywords: 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]4-quinazolinamine . 3HCl
Application: HMTase inhibitor
CAS 935693-62-2
MW: 490,6 D
31.00€ * From 27.90€ *
Review
CM-272
CM-272

Item number: Cay25948-5

CM-272 is a reversible inhibitor of the histone methyltransferases G9a and GLP, as well as DNA methyltransferase 1 (DNMT1), DNMT3A, and DNMT3B (IC50s = 8, 2, 382, 85, and 1,200 nM, respectively). It inhibits the growth of, and induces apoptosis in, CEMO-1, MV4-11, and OCI-LY10 cancer cells (GI50s = 218, 269, and 455...
Keywords: 6-methoxy-2-(5-methyl-2-furanyl)-N-(1-methyl-4-piperidinyl)-7-[3-(1-pyrrolidinyl)propoxy]-4-quinolinamine
Application: EHMT2/EHMT1/DNMT1/DNMT3A/DNMT3B inhibitor
CAS 1846570-31-7
MW: 478.6 D
From 109.00€ *
Review
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