Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay31827-100 | 100 µg | - |
6 - 10 business days* |
439.00€
|
|||
Cay31827-1 | 1 mg | - |
6 - 10 business days* |
2,852.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Low affinity immunoglobulin gamma Fc region receptor IIIb (FcgammaRIIIb) has roles in neutrophil... more
Product information "FcgammaRIIIb/CD16b HNA-1b allotype (human, recombinant)"
Low affinity immunoglobulin gamma Fc region receptor IIIb (FcgammaRIIIb) has roles in neutrophil adhesion, phagocytosis, and the respiratory burst. It is encoded by the FCGR3B gene in humans and is comprised of two immunoglobulin-like (Ig-like) extracellular domains that bind to IgG Fc and pentraxins, such as C-reactive protein. FcgammaRIIIb is synthesized as a precursor with a transmembrane domain and four-residue cytoplasmic domain that are cleaved in the endoplasmic reticulum, following which a glycosylphosphatidylinositol (GPI) anchor is added, which allows for membrane association of the mature protein. It can be expressed as three different allotypes known as human neutrophil antigens HNA-1a, HNA-1b, and HNA-1c, which are characterized by differential antibody binding affinities. FcgammaRIIIb is constitutively expressed in neutrophils and a subset of basophils and is shed from the cell surface as a soluble form via proteolytic cleavage during apoptosis or following neutrophil activation. Copy number variation of FCGR3B is associated with an increased risk of systemic lupus erythematosus (SLE) and primary Sjögren's syndrome. Cayman's FcgammaRIIIb/CD16b HNA-1b allotype (human, recombinant) protein consists of 176 amino acids and has a calculated molecular weight of 20 kDa.Synonyms: FCG3, FCGR3B, FCGR3B* 02, FCR-10, FCRIIIb. Purity: >95% estimated by SDS-PAGE. Source: Recombinant human FcgammaRIIIb expressed in E. coli. Amino Acids: 18-193. MW: 20 kDa. Formulation: (Request formulation change), Lyophilized from sterile 20 mM Tris (pH 7.4) with 50 mM sodium chloride. UniProt Accession #: O75015.
Keywords: | CD16B, CD16b, CD16b, FCGR3B, FcRIII, FcR-10, FcRIII, FcR-10, FcRIIIb, FcRIIIb, Fc-gamma RIII, Fc-gamma RIII, Fc-gamma RIIIb, Fc-gamma RIIIb, Fc-gamma RIII-beta, Fc-gamma RIII-beta, IgG Fc receptor III-1, IgG Fc receptor III-1, Low affinity immunoglobulin |
Supplier: | Cayman Chemical |
Supplier-Nr: | 31827 |
Properties
Conjugate: | No |
Purity: | >95% estimated by SDS-PAGE |
Format: | Lyophilized |
Database Information
KEGG ID : | K06463 | Matching products |
UniProt ID : | O75015 | Matching products |
Gene ID | GeneID 2215 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed