FABP1 (rat recombinant)

Fatty acid binding protein 1 (FABP1) is one of nine known cytosolic FABPs ranging in size from 14-15 kDa containing 127-132 amino acids. FABP1 is composed of ten antiparallel beta strands that form a barrel with a bigger binding pocket than the other FABPs allowing it to accommodate two fatty acids. Expression of FABP1 is decreased in hepatoblastoma and hepatocellular carcinoma making the protein a potential tumor marker. Moreover, studies have suggested FABP1 as a potential biomarker for both liver and kidney injury. Cayman's FABP1 has been functionally characterized by a fluorescence displacement assay using the fluorescent fatty acid analogue 11-(dansyl amino)undecanoic acid (DAUDA). Both arachidonic acid and oleic acid effectively displace DAUDA from the FABP binding pocket in a concentration-dependent manner.Synonyms: L-FABP, Liver-FABP, Liver-Fatty Acid Binding Protein, Fatty Acid Binding Protein 1. Purity: >90%. Source: recombinant N-terminal hexahistidine-tagged protein expressed in E. coli. MW: 18.3 kDa. Formulation: (Request formulation change), A solution in 50 mM of sodium phosphate, pH 7.2, with 20% glycerol and 150 mM sodium chloride.