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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-PKSH031224.50 | 50 µg | - |
7 - 16 business days* |
1,025.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Activity: Measured by its ability to hydrolyze the 5'phosphate groups from the substrate... more
Product information "ENTPD5 Protein (His tag) (recombinant human)"
Activity: Measured by its ability to hydrolyze the 5'phosphate groups from the substrate guanosine5'diphosphate (GDP).The specific activity is >7,000 pmoles/min/µg. Protein Construction: A DNA sequence encoding the human ENTPD5 (O75356) (Met 1-His 428) was fused with a polyhistidine tag at the C-terminus. Sequence: Met 1-His 428. Fusion tag: C-His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 45 kDa. Protein function: Ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5), also known as CD39 antigen-like 4, ER-UDPase, Guanosine-diphosphatase ENTPD5, Nucleoside diphosphatase Uridine-diphosphatase ENTPD5. This hydrolase is expressed in response to phosphoinositide 3-kinase (PI3K) signaling. Activation of PI3K results in FOXO phosphorylation by AKT1 and loss of ENTPD5 transcriptional repression. It is Up-regulated in PTEN-deficient cells. Uridine diphosphatase (UDPase) that promotes protein N-glycosylation and ATP level regulation.ENTPD5 promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, ENTPD5 constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. ENTPD5 also hydrolyzes GDP and IDP but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. This enzyme Plays a key role in the AKT1-PTEN signaling pa Protein function: Uridine diphosphatase (UDPase) that promotes protein N- glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling. [The UniProt Consortium]
Keywords: | ENTPD5, CD39L4, ER-UDPase, NTPDase 5, EC=3.6.1.6, EC=3.6.1.42, GDPase ENTPD5, UDPase ENTPD5, CD39 antigen-like 4, Nucleoside diphosphatase, Uridine-diphosphatase ENTPD5, Guanosine-diphosphatase ENTPD5, Ectonucleoside triphosphate diphosphohydrolase 5, Rec |
Supplier: | Elabscience |
Supplier-Nr: | E-PKSH031224 |
Properties
Conjugate: | No |
Host: | Insect cells |
Species reactivity: | human |
MW: | 47 kD |
Format: | Lyophilized |
Database Information
KEGG ID : | K01511 | Matching products |
UniProt ID : | O75356 | Matching products |
Gene ID | GeneID 957 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | +4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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