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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay15137-100 | 100 µg | - |
6 - 10 business days* |
611.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Eukaryotic translation initiation factor 4E (eIF4E) is a component of the eIF4 complex that... more
Product information "eIF4E (human, recombinant)"
Eukaryotic translation initiation factor 4E (eIF4E) is a component of the eIF4 complex that specifically binds to the methyl-7-guanosine cap structure at the 5' end of eukaryotic mRNA to initiate translation. Nuclear eIF4E promotes export of mRNAs that contain the eIF4E sensitivity element (4E-SE) to the cytosol while cytosolic eIF4E, in a complex with eIF4A and eIF4G1/eIF4G3, mediates recruitment of mRNAs to the ribosome to initiate cap-dependent translation. eIF14E activity is regulated by eukaryotic translation initiation factor 4E-binding proteins (4E-BPs), which bind eIF4E to prevent eIF4 complex assembly and subsequent translation. Overexpression of eIF4E is observed in approximately 30% of human malignancies, including breast, colon, and head and neck carcinomas, and acute myeloid leukemias, particularly M4 and M5 subtypes, as well as prostate cancers. Increased eIF4E expression leads to increased translation of oncogenic mRNAs, such as those encoding VEGF and cyclin D1, and contributes to cancer cell survival and proliferation.Synonyms: Eukaryotic Translation Initiation Factor 4E, mRNA Cap-binding Protein. Purity: >55% estimated by SDS-PAGE. Source: Recombinant protein expressed in E. coli. Amino Acids: 2-217 (full length). MW: 25.2 kDa. Formulation: (Request formulation change), 20 mM HEPES, pH 7.5, containing 100 mM potassium chloride, 2 mM DTT, and 10% glycerol. UniProt Accession #: P06730.
Keywords: | eIF4E, eIF4E, eIF-4E, eIF-4E, EIF4EL1, eIF-4F 25 kDa subunit, eIF-4F 25 kDa subunit, mRNA cap-binding protein {ECO:0000303|PubMed:3469651}, mRNA cap-binding protein {ECO:0000303|PubMed:3469651}, Eukaryotic translation initiation factor 4E {ECO:0000303|Pub |
Supplier: | Cayman Chemical |
Supplier-Nr: | 15137 |
Properties
Application: | Binding assays |
Conjugate: | No |
Host: | E.coli |
Species reactivity: | human |
Purity: | >55% estimated by SDS-PAGE |
Format: | Solution |
Database Information
KEGG ID : | K03259 | Matching products |
UniProt ID : | P06730 | Matching products |
Gene ID | GeneID 1977 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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