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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay23589-100 | 100 µg | - |
6 - 10 business days* |
489.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
DJ-1/Parkinson disease protein 7 (PARK7) is a dimeric protein deglycase that repairs... more
Product information "DJ-1/PARK7 (human, recombinant)"
DJ-1/Parkinson disease protein 7 (PARK7) is a dimeric protein deglycase that repairs methylglyoxal- and glyoxal-glycated cysteine, arginine, and lysine residues in oxidatively damaged proteins. It acts on early glycation intermediates (hemithioacetals and aminocarbinols) to prevent the formation of irreversibly damaged advanced glycation end products (AGEs). PARK7 also repairs methylglyoxal- and glyoxal-glycated dGTP, GTP, GDP, GMP, RNA, and DNA. Knockdown of PARK7 in vitro increases glycated DNA, DNA strand breaks, and phosphorylated p53 levels but decreases mRNA expression of the antioxidant-related enzyme NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) and destabilizes the nuclear factor erythroid 2-related factor (Nrf2), a master regulator of antioxidant transcriptional responses. . PARK7 is also a glyoxalase that converts glyoxal and methylglyoxal to glycolic and lactic acid, respectively, in the absence of glutathione. It acts as a redox-sensitive molecular chaperone and inhibits aggregation of alpha-synuclein in cell-free assays and in murine neuroblastoma cells. PARK7 forms a complex with the E3 ubiquitin ligase Parkin and PTEN-induced putative kinase 1 (PINK1) that promotes ubiquitination and degradation of Parkin substrates, including Parkin itself and Synphilin-1 in neuroblastoma SH-SY5Y cells and human brain lysates. Mutations to PARK7 have been linked to autosomal recessive, early-onset Parkinson's disease.Synonyms: Parkinson Deglycase DJ-1, Parkinson Disease Protein 7. Purity: >90% estimated by SDS-PAGE. Source: Recombinant N-terminal His-tagged PARK7 enzyme expressed in E. coli. Amino Acids: 2-189. MW: 22 kDa. Formulation: (Request formulation change), 50 mM HEPES, pH 8.0, 150 mM sodium chloride, and 10% glycerol. UniProt Accession #: Q99497.
Keywords: | DJ-1, DJ-1, Oncogene DJ1, Protein DJ-1, Oncogene DJ1, Protein DJ-1, Maillard deglycase, Maillard deglycase, Parkinson disease protein 7, Parkinson disease protein 7, Parkinsonism-associated deglycase, Parkinsonism-associated deglycase, Protein/nucleic aci |
Supplier: | Cayman Chemical |
Supplier-Nr: | 23589 |
Properties
Application: | ELISA, HTS, WB |
Conjugate: | No |
Species reactivity: | human |
Purity: | >90% estimated by SDS-PAGE |
Format: | Solution |
Database Information
KEGG ID : | K05687 | Matching products |
UniProt ID : | Q99497 | Matching products |
Gene ID | GeneID 11315 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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