Cytokine receptor common subunit gamma Protein (recombinant human)

Activity: Measured by its ability to bind biotinylated recombinant rat IL2 in a functional ELISA. Protein Construction: Recombinant Human Cytokine receptor common subunit gamma is produced by our Mammalian expression system and the target gene encoding Leu23-Ala262 is expressed with a Fc tag at the C-terminus. Sequence: Leu23-Ala262. Fusion tag: C-Fc Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 85-100 kDa. Protein function: IL2RG contains one fibronectin type-III domain. IL2RG is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. IL2RG interacts with SHB upon interleukin stimulation and HTLV-1 accessory protein p12I. Defects in IL2RG are the cause of X-linked combined immunodeficiency (XCID) and severe combined immunodeficiency X-linked T-cell-negative /B-cell-positive / NK-cell-negative (XSCID). Protein function: Common subunit for the receptors for a variety of interleukins. [The UniProt Consortium]