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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-PKSM040987.10 | 10 µg | - |
7 - 16 business days* |
133.00€
|
|||
E-PKSM040987.50 | 50 µg | - |
7 - 16 business days* |
352.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein Construction: Recombinant Mouse Collagen alpha-1(XVIII) chain is produced by our... more
Product information "Collagen Alpha-1(XVIII) Chain/EndostatinProtein(C-6His) (recombinant mouse)"
Protein Construction: Recombinant Mouse Collagen alpha-1(XVIII) chain is produced by our Mammalian expression system and the target gene encoding His1591-Lys1774 is expressed with a 6His tag at the C-terminus. Sequence: His1591-Lys1774. Fusion tag: C-6His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 18 kDa. Protein function: Endostatin, an endogenous non-glycosylated inhibitor of endothelial cell proliferation and angiogenesis. It is produced and/or trimmed by metalloproteinases such as MMP-2 and MMP-9, and cathepsins S, B and L. The N-terminal ~27 aa of Endostatin appear to contain the majority of its activity. This region contains zinc binding sites that are thought to be critical for its anti-endothelial and anti-tumor effects, as well as multiple cleavage sites that, when used, can modify its activity. Mouse Endostatin shares 96% aa sequence identity with rat and 85-87% with human, bovine and equine Endostatin. It is predominantly expressed in liver, kidney, lung, skeletal muscle and testis. Endostatin inhibits endothelial cell growth by inducing cell cycle arrest in G1 phase and initiating apoptosis. It is also thought to down-regulate angiogenesis by blocking VEGF-induced endothelial cell migration. Endostatin may also be involved with down-regulation of angiogenesis after establishment of placental circulation in the preg Protein function: Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. [The UniProt Consortium]
Keywords: | Col18a1, Recombinant Mouse Collagen Alpha-1(XVIII) Chain/EndostatinProtein(C-6His) |
Supplier: | Elabscience |
Supplier-Nr: | E-PKSM040987 |
Properties
Conjugate: | No |
Host: | Human cells |
Species reactivity: | mouse |
MW: | 21.2 kD |
Format: | Lyophilized |
Database Information
KEGG ID : | K06823 | Matching products |
UniProt ID : | P39061 | Matching products |
Gene ID | GeneID 12822 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | +4°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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