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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
C7510-11V.20 | 20 µg | - | - |
3 - 19 business days* |
1,021.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Type I collagen is the most abundant structural protein of connective tissues such as skin, bone... more
Product information "COL1A1, Recombinant, Human (Collagen alpha-1(I) Chain, Alpha-1 Type I Collagen)"
Type I collagen is the most abundant structural protein of connective tissues such as skin, bone and tendon. It is synthesized as a procollagen molecule which is characterized by a 300nm triple helical domain flanked by globular N- and C-terminal propeptides. The triple helical domain contains Gly-Xaa-Yaa triplets where Xaa and Yaa are frequently proline and hydroxyproline, respectively. The non-helical propeptides are removed by procollagen N- and C-proteinase activities so that the mature triple helices can self-assemble into collagen fibrils that provide tensile strength to tissues. Type I collagen is a heterotrimer that consists of two alpha1(I) chains and one alpha2(I) chain, although homotrimers consisting of three identical alpha1 (I) chains have also been described. This recombinant mini pro-alpha1(I) collagen is a homotrimer of three shortened alpha1(I) chains with following domain structure from N-to C-terminus: N-propeptide, N-telopeptide, the 33 most N-terminal Gly-Xaa-Yaa repeats, the 33 most C-terminal Gly-Xaa-Yaa repeats, C-telopeptide and C-propeptide. The preparation contains a mixture of the full-length molecule, pN collagen I(alpha1) and the C-terminal propeptide. This truncated pro-alpha1(I) collagen is a substrate for procollagen N-proteinase and procollagen C-proteinase. Source: Chinese Hamster Ovary cell line, CHO-derived Gln23-Lys277+Gly1094-Leu1464, with an N-terminal human CD33 signal sequence and 6-His tag. SDS-PAGE: 79-83kD, 54-56kD, 35-36kD, reducing conditions, Activity: Measured by the cleavage of its C-terminal propeptide by recombinant human BMP-1. 50% of full-length Pro Collagen I alpha1 is cleaved by rhBMP-1. Endotoxin Level: <1EU/1ug (LAL) , Storage and Stability:, Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | COL1A1, Alpha-1 type I collagen, Collagen alpha-1(I) chain |
Supplier: | United States Biological |
Supplier-Nr: | C7510-11V |
Properties
Conjugate: | No |
Species reactivity: | human |
Format: | Purified |
Database Information
KEGG ID : | K06236 | Matching products |
UniProt ID : | P02452 | Matching products |
Gene ID | GeneID 1277 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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