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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-PKSR030146.100 | 100 µg | - |
7 - 16 business days* |
869.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein Construction: A DNA sequence encoding the rat Clps (NP_037271.1) (Met1-Gln112) was... more
Product information "CLPS / Colipase Protein (His Tag) (recombinant rat)"
Protein Construction: A DNA sequence encoding the rat Clps (NP_037271.1) (Met1-Gln112) was expressed with a polyhistidine tag at the C-terminus. Sequence: Met1-Gln112. Fusion tag: C-His Endotoxin: < 1.0 EU per µg protein as determined by the LAL method. Protein function: Colipase belongs to the colipase family. Structural studies of the complex and of colipase alone have revealed the functionality of its architecture. It is a small protein with five conserved disulphide bonds. Structural analogies have been recognised between a developmental protein, the pancreatic lipase C-terminal domain, the N-terminal domains of lipoxygenases and the C-terminal domain of alpha-toxin. Colipase can only be detected in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Colipase allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. Colipase is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilising as active conformation and considerably increasing the overall hydro Protein function: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. [The UniProt Consortium]
Keywords: | Clps, Colipase, Recombinant Rat CLPS / Colipase Protein (His Tag) |
Supplier: | Elabscience |
Supplier-Nr: | E-PKSR030146 |
Properties
Conjugate: | No |
Host: | Human cells |
Species reactivity: | rat |
MW: | 11.9 kD |
Format: | Lyophilized |
Database Information
KEGG ID : | K14460 | Matching products |
UniProt ID : | P17084 | Matching products |
Gene ID | GeneID 25680 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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