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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-PKSH032256.10 | 10 µg | - |
7 - 16 business days* |
117.00€
|
|||
E-PKSH032256.50 | 50 µg | - |
7 - 16 business days* |
311.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein Construction: Recombinant Human C-Type Lectin Domain Family 10 Member A is produced by... more
Product information "CLEC10A/CD301 Protein(C-6His) (recombinant human)"
Protein Construction: Recombinant Human C-Type Lectin Domain Family 10 Member A is produced by our Mammalian expression system and the target gene encoding Gln61-His316 is expressed with a 6His tag at the C-terminus. Sequence: Gln61-His316. Fusion tag: C-6His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 40 kDa. Protein function: C-Type Lectin Domain Family 10 Member A (CLEC10A) is a type II transmembrane C-type lectin that is expressed on immature myleloid dendritic cells and alternatively activated (tolerogenic) macrophages. CLEC10A/MGL binds and internalizes molecules with terminal nonsialylated GalNAc carbohydrates such as the Tn carcinoma antigen. CLEC10A/MGL also binds the GP envelope glycoprotein on Marburg and Ebola viruses and enhances viral entry and infectivity. It constitute a unique class of C-type lectins because of their specificity for galactose and its structural homologues. CLEC10A is thought to participate in the recognition of molecules from both altered self and pathogens due to its monosaccharide specificity for Gal and N-acetylgalactosamine (GalNAc). Human and rat carry a single gene for CLEC10A/MGL, while mouse has two closely related MGL1 and MGL2 genes. Protein function: Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells. [The UniProt Consortium]
Keywords: | CD301, CLEC10A, CLECSF13, Macrophage lectin 2, C-type lectin superfamily member 14, C-type lectin domain family 10 member A, Recombinant Human CLEC10A/CD301 Protein(C-6His) |
Supplier: | Elabscience |
Supplier-Nr: | E-PKSH032256 |
Properties
Conjugate: | No |
Host: | Human cells |
Species reactivity: | human |
MW: | 29.8 kD |
Format: | Lyophilized |
Database Information
KEGG ID : | K06721 | Matching products |
UniProt ID : | Q8IUN9 | Matching products |
Gene ID | GeneID 10462 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | +4°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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