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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay37780-100 | 100 µg | - |
6 - 10 business days* |
854.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Nucleophosmin is a nucleolar phosphoprotein that is involved in diverse biological processes,... more
Product information "Citrullinated Nucleophosmin (human, recombinant)"
Nucleophosmin is a nucleolar phosphoprotein that is involved in diverse biological processes, including ribosome maturation, DNA repair, and mitotic spindle assembly. It is highly post-translationally modified and composed of an oligomerization domain, which contains two nuclear export signals, three acidic domains, an intrinsically disordered region, which contains two nuclear localization signals, and a C-terminal RNA-binding domain. Nucleophosmin is ubiquitously expressed and shuttles between the nucleolus and cytoplasm, however, alternative splicing of NPM1 produces a variant that lacks the RNA-binding domain and nucleolar localization signal and is instead localized throughout the nucleus. Nucleophosmin has histone- and protein chaperone activity and plays a role in ribosome assembly and export, centrosome duplication, cell cycle control, the stress response, and embryogenesis. Nucleophosmin citrullinated by PAD4 increases p53 stability and radiation sensitivity in a thyroid cancer cell line exposed to radiation. This product contains purified nucleophosmin (Cay-37621) that has been modified with PAD4, which is subsequently depleted by affinity chromatography.Synonyms: NPM, NPM1, Nucleolar Phosphoprotein B23, Nucleolar Protein NO38, Numatrin. Purity: >60% estimated by SDS-PAGE. Source: Recombinant human N-terminal His-TEV-tagged NPM1 expressed in E. coli and citrullinated by PAD4. Amino Acids: 2-294 (full length). MW: 34.7 kDa. Formulation: (Request formulation change), 50 mM HEPES, pH 7.8, with 150 mM sodium chloride and 10% glycerol. UniProt Accession #: P06748.
Keywords: | NPM, NPM, NPM, NPM1, Numatrin, Numatrin, Nucleophosmin, Nucleophosmin, Nucleolar protein NO38, Nucleolar protein NO38, Nucleolar phosphoprotein B23, Nucleolar phosphoprotein B23 |
Supplier: | Cayman Chemical |
Supplier-Nr: | 37780 |
Properties
Application: | SDS-PAGE, MS |
Conjugate: | No |
Host: | E.coli |
Species reactivity: | human |
MW: | 34.7 kD |
Purity: | >60% estimated by SDS-PAGE |
Format: | Solution |
Database Information
KEGG ID : | K11276 | Matching products |
UniProt ID : | P06748 | Matching products |
Gene ID | GeneID 4869 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Signal Word: | Warning |
H Phrases: | H316, H333 |
P Phrases: | P304+312, P332+313 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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