CHI3L1/YKL40 protein (His tag), recombinant mouse

Activity: Testing in progress Protein Construction: A DNA sequence encoding the Mouse CHI3L1/YKL40 protein (Q61362) (Tyr 30-Ala 389) was expressed with N-His tag. Sequence: Tyr 30-Ala 389. Fusion tag: N-His Endotoxin: Please contact us for more information. Apparent Molecular Mass: 42 kDa. Protein function: Chitinase-3-like protein 1 (CHI3L1) is a secreted heparin-binding glycoprotein whose expression is associated with vascular smooth muscle cell migration. CHI3L1 is expressed at high levels in postconfluent nodular VSMC cultures and at low levels in subcon Protein function: Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia- induced injury, inflammation and epithelial apoptosis in lung. [The UniProt Consortium]