CD279 [PD-1] (human)-muIg Fusion Protein

CD279 [PD-1] (human)-muIg Fusion Protein
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ANC-549-020 25 µg -

3 - 9 business days*

450.00€
 
A soluble fusion protein consisting of the extracellular (139aa) domain of human CD279(PD-1) and... more
Product information "CD279 [PD-1] (human)-muIg Fusion Protein"
A soluble fusion protein consisting of the extracellular (139aa) domain of human CD279(PD-1) and murine IgG2a Fc +hinge. In SDS-PAGE, this protein runs at 52 kd under native, and 27 kd under reducing conditions. Data suggest that the murine Ig Fc proximal portion of this construct may be prone to cleavage. Human CD279 (PD-1, Programmed death 1) is a 55 kd Ig superfamily member with similarity to CD28 and CD152(CTLA-4). It is expressed on activated T and B and myeloid cells, and engagement by its ligands PD-L1 (CD274, B7-H1) or PD-L2 (B7-DC) can inhibit proliferation and cytokine expression. In mice blockade of PD-1 ligand interaction has been used to augment T cell anti cancer responses. Recombinant CD279 -muIg binds to recombinant CD274 and CD273 in EIA and cell surface CD273 on moDC in FACS. It is recognized by anti-CD279 mAb (cat #279-030, clone ANC4H6) in EIA.
Keywords: PD1, CD279, hPD-1, PDCD1, Protein PD-1, Programmed cell death protein 1
Supplier: Ancell
Supplier-Nr: 549-020

Properties

Application: ELISA, FC
Conjugate: No
Expressed in: Hamster cells
Origin: Human
MW: 27 kD
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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