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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay32015-100 | 100 µg | - |
6 - 10 business days* |
439.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
CD1b is a member of the CD1 family of transmembrane glycoproteins and is an MHC class I-like... more
Product information "CD1b Long Isoform Extracellular Ligand-binding Domain (human, recombinant)"
CD1b is a member of the CD1 family of transmembrane glycoproteins and is an MHC class I-like molecule that presents lipid antigens to T cells. Alternative splicing of CD1B produces one full-length isoform, CD1b long, and one short isoform. CD1b long exists as a tetramer where each monomer is composed of a transmembrane CD1 heavy chain that contains three extracellular domains (alpha1-alpha3), which associate with beta2-microglobulin to form a lipid-binding groove, as well as a cytoplasmic tail that contains a YXXZ endosomal sorting motif and interacts with the chaperone proteins AP-2 and AP-3 to direct CD1b intracellular trafficking. The CD1b short isoform lacks the endosomal sorting motif and is confined to the cell surface. CD1b expression is induced in antigen-presenting cells by bacteria or toll-like receptor 2 (TLR2), IL-1beta, or GM-CSF stimulation and functions to present a variety of lipid antigens to T cells. CD1b is synthesized in the endoplasmic reticulum and is transported to the cell membrane where it expresses self-lipids, such as sphingolipids and phospholipids. It is then internalized and localizes to the late endosome or lysosome where it exchanges self-lipids for pathogen-derived lipids, including mycolates and lipoglycans, prior to being re-expressed on the cell surface for T cell presentation. CD1b protein levels are increased in skin lesions from patients with leprosy, in lung granulomas from patients with tuberculosis, and in postmortem-derived brain lesions from patients with multiple sclerosis. CD1B SNPs have been found in patients with prostate cancer. Cayman's CD1b Long Isoform Extracellular Ligand-binding Domain (human, recombinant) protein is a disulfide-linked homodimer. The reduced monomer, comprised of CD1b Long Isoform Extracellular Ligand-binding Domain (amino acids 18-303) fused to human IgG1 Fc at its C-terminus, consists of 527 amino acids, has a calculated molecular weight of 58.6 kDa, and a predicted N-terminus of Ser18. As a result of glycosylation, the monomer migrates at approximately 59 to 69 kDa by SDS-PAGE under reducing conditions.Synonyms: R1. Purity: >88% estimated by SDS-PAGE. Endotoxin Testing: < 1.0 EU/µg, determined by the LAL endotoxin assay. Source: Recombinant C-terminal human IgG1 Fc-His-tagged CD1b expressed in HEK293 cells. Amino Acids: 18-303. MW: 58.6 kDa. Formulation: (Request formulation change), Lyophilized from sterile PBS, pH 7.4. UniProt Accession #: P29016.
Keywords: | CD1B, CD1b, CD1b, T-cell surface glycoprotein CD1b, T-cell surface glycoprotein CD1b |
Supplier: | Cayman Chemical |
Supplier-Nr: | 32015 |
Properties
Conjugate: | No |
Purity: | >88% estimated by SDS-PAGE |
Format: | Lyophilized |
Database Information
KEGG ID : | K06448 | Matching products |
UniProt ID : | P29016 | Matching products |
Gene ID | GeneID 910 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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