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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
AG-40B-0232-C050 | 50 µg | - | - |
3 - 9 business days* |
220.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
CD152 (Cytotoxic T-lymphocyte-associated protein 4, CTLA-4) is an inhibitory receptor belonging... more
Product information "CD152 [CTLA-4] (human) (rec.) (untagged)"
CD152 (Cytotoxic T-lymphocyte-associated protein 4, CTLA-4) is an inhibitory receptor belonging to the CD28 immunoglobulin subfamily, expressed primarily by T cells. Its ligands, CD80 and CD86, are typically found on the surface of antigen-presenting cells and can either bind CD28 or CTLA-4, resulting in a costimulatory or a co-inhibitory response, respectively. Because of its dampening effect, CTLA-4 is a crucial regulator of T cell homeostasis and self-tolerance. While CD28 promotes T cell activation and proliferation, CTLA-4 is reported to dampen T cell responses through a variety of mechanisms. Prior to activation, conventional T cells (Tconv) express low levels of CTLA-4, predominantly in intracellular compartments. Upon activation, CTLA-4 expression is upregulated and becomes increasingly detectable on the cell surface. In Tregs on the other hand, transmembrane CTLA-4 is constitutively expressed and plays an important role in Treg homeostasis and function. In general, T cell CTLA-4 is largely constrained to intracellular expression although some surface expression may be detectable owing to the rapid, continuous shuttling of CTLA-4 between intracellular compartments and the plasma membrane. Recently, CTLA-4 has been studied in dendritic cells and tumors, showing that CTLA-4 plays nonredundant and critical roles in thymic development, T cell priming, peripheral tolerance, and a variety of other critical immunoregulatory functions as an immune checkpoint in Immuno-oncology research.
Keywords: | Cytotoxic T-lymphocyte-associated Antigen 4, Cytotoxic T-lymphocyte Protein 4 |
Supplier: | AdipoGen Life Sciences |
Supplier-Nr: | AG-40B-0232 |
Properties
Application: | Human CD80 binding |
Conjugate: | No |
Host: | Human cells |
Species reactivity: | human |
MW: | 18 kD |
Purity: | >95% (SDS-PAGE) |
Format: | Solid |
Database Information
KEGG ID : | K06538 | Matching products |
UniProt ID : | P16410 | Matching products |
Gene ID | GeneID 1493 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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