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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
CHI-HR-200CD137-C025 | 25 µg | - | - |
3 - 9 business days* |
352.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Human CD137 (aa 19-184) is fused at the C-terminus to a His-tag. Human CD137 (4-1BB) is a... more
Product information "CD137 (human) (rec.) (His)"
Human CD137 (aa 19-184) is fused at the C-terminus to a His-tag. Human CD137 (4-1BB) is a costimulatory molecule of the tumor necrosis factor (TNF) receptor superfamily. The glycoprotein 4-1BB is expressed mainly on activated CD4+ and CD8+ T cells and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4-1BB is associated with the tumor receptor-associated factors (TRAF), the adaptor protein and mediates downstream signaling events including the activation of NF-?B and cytokine production. 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T cell activation and growth as well as monocyte proliferation and B cell survival, and plays a important role in the amplification of T cell-mediated immune responses. In contrast, it can also enhance activation-induced T cell apoptosis when triggered by engagement of the TCR/CD3 complex. In addition, the 4-1BB/4-1BBL costimulatory pathway has been shown to augment secondary CTL responses to several viruses and increase antitumor immunity. 4-1BB is therefore a promising candidate for immunotherapy of human cancer.
Keywords: | CD137, CDw137, TNFRSF9, T-cell antigen ILA, 4-1BB ligand receptor, T-cell antigen 4-1BB homolog, Tumor necrosis factor receptor superfamily member 9 |
Supplier: | Chimerigen Laboratories |
Supplier-Nr: | HR-200CD137 |
Properties
Application: | Bioassays |
Conjugate: | No |
Host: | E.coli |
Species reactivity: | human |
Purity: | >95% |
Format: | Lyophilized |
Database Information
KEGG ID : | K05146 | Matching products |
UniProt ID : | Q07011 | Matching products |
Gene ID | GeneID 3604 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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