CAMK1D Protein (GST Tag) (recombinant human)

Protein Construction: Recombinant Human CAMK1D is produced by our E.coli expression system and the target gene encoding Met1-Lys385 is expressed with a GST tag at the N-terminus. Sequence: Met1-Lys385. Fusion tag: N-GST Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 60-70 kDa. Protein function: CAMK1D is a serine threonine kinase that is a member of the calcium?calmodulin-dependent protein kinase family. It contains a protein kinase domain. CAMK1D expressed in polymorphonuclear leukocytes and may be part of the chemokine signal transduction pathway that regulates granulocyte function. It may also be involved in modulation of neuronal apoptosis. It activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. Protein function: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium- mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta. [The UniProt Consortium]