Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
518976.100 | 100 µg | - | - |
3 - 19 business days* |
1,099.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
C-type lectin domain family 4, member M (CLEC4M), also known as L-SIGN, is a type II integral... more
Product information "C-type Lectin Domain Family 4 Member M (CLEC4M), Recombinant, Human, aa71-399, His-Tag"
C-type lectin domain family 4, member M (CLEC4M), also known as L-SIGN, is a type II integral membrane protein that has 77% amino acid identity to DC-SIGN. CLEC4M is expressed predominantly on endothelial cells of liver and lymph nodes but not on dendritic cells. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23aa repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. CLEC4M is believed to be involved in peripheral immune surveillance in the liver, mediating endocytosis of pathogens for degradation in lysosomal compartments. It appears to selectively recognize and bind a variety of viral surface glycoproteins containing high mannose N-linked oligosaccharides in a calcium-dependent manner, including HIV-1 gp120, HIV-2 gp120, SIV gp120, Ebola virus glycoproteins, HCV E2, and human SARS coronavirus protein S, as well as the cellular adhesion protein ICAM3. CLEC4M likley plays an important role in establishing HIV infection by enhancing trans-infection of CD4(+)T cells in regional lymph nodes. It is also a liver-specific receptor for HCV envelope glycoprotein E2, and both CLEC4M and DC-SIGN may play critical roles in viral pathogenesis and tissue tropism (Gardner, et al., 2003). Its polymorphism may also affect HCV loads and contribute to HCV replication efficacy (Lozach, et al., 2004). It is also a cofactor for cellular entry by Ebola virus (Alvarez, et al., 2002) and a SARS-CoV binding receptor, homozygosity for CLEC4M is believed to play a protective role during SARS infection (Chan, et al., 2006). CLEC4M and DC-SIGN can also function as attachment receptors for Sindbis (SB) virus, an arbovirus of the Alphavirus genus (Klimstra, et al., 2003). Recombinant protein corresponding to aa71-399 of human CLEC4M, fused to 6xHis-Tag at N-terminal, expressed in HEK293 cells. , Storage and Stability:, Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | CD299, CLEC4M, L-SIGN, CD209L, DC-SIGNR, DC-SIGN2, DC-SIGN-related protein, CD209 antigen-like protein 1, C-type lectin domain family 4 member M, Dendritic cell-specific ICAM-3-grabbing non-integrin 2 |
Supplier: | United States Biological |
Supplier-Nr: | 518976 |
Properties
Conjugate: | No |
Species reactivity: | human |
Purity: | >=95% |
Format: | Highly Purified |
Database Information
KEGG ID : | K06563 | Matching products |
UniProt ID : | Q9H2X3 | Matching products |
Gene ID | GeneID 10332 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed