BTNL2/Butyrophilin-like Protein 2 Protein (His Tag) (recombinant mouse)

BTNL2/Butyrophilin-like Protein 2 Protein (His Tag) (recombinant mouse)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-PKSM041354.10 10 µg -

7 - 16 business days*

133.00€
E-PKSM041354.50 50 µg -

7 - 16 business days*

352.00€
 
Protein Construction: Recombinant Mouse Butyrophilin-like Protein 2 is produced by our Mammalian... more
Product information "BTNL2/Butyrophilin-like Protein 2 Protein (His Tag) (recombinant mouse)"
Protein Construction: Recombinant Mouse Butyrophilin-like Protein 2 is produced by our Mammalian expression system and the target gene encoding Asp27-Ser452 is expressed with a 6His tag at the C-terminus. Sequence: Asp27-Ser452. Fusion tag: C-His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 55-65 kDa. Protein function: Butyrophilin-like 2 (BTNL2) is a member of the BTN/MOG Ig-superfamily and functions as a negative regulator of immune cell activation. Mouse BTNL2 is type I transmembrane glycoprotein that contains an extracellular domain (ECD), a transmembrane region and a short cytoplasmic domain. The ECD features two V-type Ig-like domains, two C-type Ig-like domains, and four glycosylation sites. BTNL2 is expressed in epithelial cells of the small intestine, colonic dendritic cells, and in cells of the lymph node. BTNL2 expression is upregulated in T cells following activation, a characteristic BTNL2 shares with the homologous B7 family of costimulatory molecules. BTNL2 negatively regulates T cells by inhibiting proliferation and inflammatory cytokine secretion. It also increases the expression of FoxP3 in T cells to promote regulatory T cell development. Single nucleotide polymorphisms in BTNL2 are associated with a risk for sporadic prostate cancer, rheumatoid arthritis, sarcoidosis, ulcerative colitis, and other inflammatory diseases. Protein function: Negative regulator of T-cell proliferation. [The UniProt Consortium]
Keywords: Gm315, Btnl2, Butyrophilin-like protein 2, Recombinant Mouse BTNL2/Butyrophilin-like Protein 2 Protein (His Tag)
Supplier: Elabscience
Supplier-Nr: E-PKSM041354

Properties

Conjugate: No
Host: Human cells
Species reactivity: mouse
MW: 486 kD
Format: Lyophilized

Database Information

UniProt ID : O70355 | Matching products
Gene ID GeneID 547431 | Matching products

Handling & Safety

Storage: -80°C
Shipping: 4°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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