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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay14645-100 | 100 µg | - |
6 - 10 business days* |
415.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
beta-Secretase 1 (BACE1) is an aspartic protease and member of the peptidase A1 protease family.... more
Product information "BACE1 (human, recombinant)"
beta-Secretase 1 (BACE1) is an aspartic protease and member of the peptidase A1 protease family. BACE1 is transcribed as a preprotein composed of an N-terminal signal peptide, a pro-peptide, a catalytic domain, a transmembrane domain, and a cytosolic domain. The N-terminal signal peptide traffics the BACE1 preprotein to the endoplasmic reticulum where furin-mediated cleavage of the propeptide produces mature BACE1. The transmembrane domain of mature BACE1 drives localization to the Golgi where BACE1 is post-translationally activated and functions at endosomal or Golgi membranes. BACE1 is expressed primarily in the brain and at lower levels in pancreatic beta-cells, adipocytes, hepatocytes, and vascular cells. BACE1 cleaves amyloid precursor protein (APP) to initiate the generation of amyloid-beta (Abeta), and BACE1 knockout rescues memory deficits and cholinergic dysfunction in transgenic mouse models of Alzheimer's disease. Additional BACE1 substrates include seizure-related 6 (SEZ6) and seizure-related 6-like (SEZ6L), and BACE1-mediated cleavage of Sez6 and Sez6L is increased in the brain in a mouse model of Niemann-Pick type C disease. Cayman's BACE1 (human, recombinant) protein can be used for enzyme activity assays.Synonyms: beta-site Amyloid Precursor Protein Cleaving Enzyme 1, ASP-2, BACE, Memapsin 2, Membrane-bound Aspartic Protease, beta-secretase 1. Purity: >85% estimated by SDS-PAGE. Source: Active recombinant human C-terminal His-tagged BACE1 expressed in insect cells. Amino Acids: 57-454. MW: 48.4 kDa. Formulation: (Request formulation change), 50 mM HEPES, pH 7.4, with 150 mM sodium chloride and 20% glycerol. UniProt Accession #: P56817.
Keywords: | BACE, Beta-secretase 1 {ECO:0000305}, Beta-secretase 1 {ECO:0000305}, Beta-site APP cleaving enzyme 1, Beta-site APP cleaving enzyme 1, ASP2 {ECO:0000303|PubMed:10656250}, ASP2 {ECO:0000303|PubMed:10656250}, Asp 2 {ECO:0000303|PubMed:10656250}, Asp 2 {ECO |
Supplier: | Cayman Chemical |
Supplier-Nr: | 14645 |
Properties
Application: | Enzyme assays |
Conjugate: | No |
Host: | Insect cells |
Species reactivity: | human |
Purity: | >85% estimated by SDS-PAGE |
Format: | Solution |
Database Information
KEGG ID : | K04521 | Matching products |
UniProt ID : | P56817 | Matching products |
Gene ID | GeneID 23621 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Signal Word: | Warning |
H Phrases: | H316, H333 |
P Phrases: | P304+312, P332+313 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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