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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay10946-50 | 50 µg | - |
6 - 10 business days* |
489.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
ASH2L is the human homolog of the Drosophila absent, small or homeotic discs 2 (ash2) gene... more
Product information "ASH2L (human recombinant)"
ASH2L is the human homolog of the Drosophila absent, small or homeotic discs 2 (ash2) gene product, a member of the trithorax group (TrxG) of proteins. The TrxG gene products in Drosophila and their mammalian homologs are responsible for controlling gene transcription. The ASH2L protein is a component of various multisubunit protein complexes, including the large complex of proteins associated with the SET1 (MLL) family of lysine methyltransferases. ASH2L, along with WDR5 and RbBP5, form the human MLL1 core protein complex. MLL1-5 protein complexes catalyze the di- and trimethylation of histone H3 at lysine 4 (H3K4me2/me3), leading to the maintenance of global H3K4 trimethylation. Post-translational modifications of ASH2L have also been described showing methylation of Arg-296 by protein-arginine methyltransferease 1 (PRMT1) in vitro and in cells and by PRMT5 in vitro. Further experimental evidence in rats suggests that ASH2L cooperates with Ha-RAS to transform rat embryonic fibroblasts, implicating ASH2L as a novel oncoprotein.Synonyms: Absent, small, or homeotic discs 2-like, Set1/Ash2 Histone Methyltransferase Complex Subunit Ash2 Isoform A. Purity: >90%. Source: Recombinant protein expressed in E. coli with a SUMO tag. Amino Acids: 96-628. MW: 60.1 kDa. Formulation: (Request formulation change), 50 mM Tris, pH 8.0, with 150 mM sodium chloride and 20% glycerol.
Keywords: | Absent, small, or homeotic discs 2-like, Set1/Ash2 Histone Methyltransferase Complex Subunit Ash2 Isoform A |
Supplier: | Cayman Chemical |
Supplier-Nr: | 10946 |
Properties
Application: | Enzyme activity |
Conjugate: | No |
Host: | E.coli |
MW: | 60,1 kD |
Purity: | >90% |
Format: | Solution |
Database Information
KEGG ID : | K14964 | Matching products |
UniProt ID : | Q9UBL3 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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