AICDA, Recombinant, Human, aa1-198aa, His-Tag (Activation-induced cytidine deaminase)

AICDA, also known as AID, is involved in somatic hypermutation, gene conversion, and class-switch recombination in B-lymphocytes. This protein is required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. It may also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Source: Recombinant protein corresponding to aa1-198 of human AICDA, fused to His-tag at N-terminal expressed in E. coli. Molecular Weight: ~26.1kD, AA Sequence: MGSSHHHHHH SSGLVPRGSH MDSLLMNRRK FLYQFKNVRW AKGRRETYLC YVVKRRDSAT SFSLDFGYLR NKNGCHVELL FLRYISDWDL DPGRCYRVTW FTSWSPCYDC ARHVADFLRG NPNLSLRIFT ARLYFCEDRK AEPEGLRRLH RAGVQIAIMT FKDYFYCWNT FVENHERTFK AWEGLHENSV RLSRQLRRIL LPLYEVDDLR DAFRTLGL, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.