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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-PKSH033291.10 | 10 µg | - |
7 - 16 business days* |
212.00€
|
|||
E-PKSH033291.50 | 50 µg | - |
7 - 16 business days* |
622.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein Construction: Recombinant Human Acid sphingomyelinase-like phosphodiesterase 3a is... more
Product information "Acid sphingomyelinase-like phosphodiesterase 3a Protein (recombinant human)"
Protein Construction: Recombinant Human Acid sphingomyelinase-like phosphodiesterase 3a is produced by our Mammalian expression system and the target gene encoding Leu23-Tyr453 is expressed with a 6His tag at the C-terminus. Sequence: Leu23-Tyr453. Fusion tag: C-6His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 49.9 kDa. Protein function: Acid sphingomyelinase-like phosphodiesterase 3a (SMPDL3A ) is a novel liver X receptor (LXR) -regulated gene, with an LXR response element within its promoter. The induction of SMPDL3A is LXR-dependent and is restricted to human blood cells with no induction observed in mouse cellular systems. LXR function as physiological sensors of cholesterol metabolites (oxysterols), regulating key genes involved in cholesterol and lipid metabolism. LXRs have been extensively studied in both human and rodent cell systems, revealing their potential therapeutic value in the contexts of atherosclerosis and inflammatory diseases. Protein function: Has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP (PubMed:25288789, PubMed:26783088). Has in vitro activity with p-nitrophenyl-TMP (PubMed:25288789). Has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphates (PubMed:25288789, PubMed:26783088). Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine. Has in vitro activity with CDP-ethanolamine (PubMed:26783088). Does not have sphingomyelin phosphodiesterase activity (PubMed:25288789, PubMed:26783088). [The UniProt Consortium]
Keywords: | ASML3A, SMPDL3A, ASM-like phosphodiesterase 3a, Acid sphingomyelinase-like phosphodiesterase 3a, Recombinant Human Acid sphingomyelinase-like phosphodiesterase 3a Protein |
Supplier: | Elabscience |
Supplier-Nr: | E-PKSH033291 |
Properties
Conjugate: | No |
Host: | Human cells |
Species reactivity: | human |
MW: | 49.9 kD |
Format: | Lyophilized |
Database Information
KEGG ID : | K01128 | Matching products |
UniProt ID : | Q92484 | Matching products |
Gene ID | GeneID 10924 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | +4°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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