ACE2 (mouse) (rec.)

ACE2 (mouse) (rec.)
COVID-19 Research
Item number Size Datasheet Manual SDS Delivery time Quantity Price
AG-40B-0193-C050 50 µg -

3 - 9 business days*

429.00€
AG-40B-0193-3050 150 µg (3 x 50 µg) -

3 - 9 business days*

858.00€
 
Extracellular domain of mouse ACE2 (aa 18-740) are fused at the C-terminus to a FLAG(R)-tag.... more
Product information "ACE2 (mouse) (rec.)"
Extracellular domain of mouse ACE2 (aa 18-740) are fused at the C-terminus to a FLAG(R)-tag. Protein function: Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. May have a protective role in acute lung injury. [The UniProt Consortium] Angiotensin-converting enzyme2 (ACE2) is an ectoenzyme (carboxypeptidase) with an extracellular catalytic domain that predominantly localizes at the plasma membrane and is thereby able to hydrolyze circulating peptides. ACE2 has approximately 42% sequence identity with ACE, and its cytoplasmic and transmembrane domains show 48% homology to the protein collectrin that plays a critical role in the amino acid absorption of the kidney. ACE2 converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. ACE2 is involved in the regulation of systemic blood pressure and has direct effects on cardiac functions. It is expressed predominantly in endothelial cells of the lung, gut, heart and kidney. ACE2 together with the protease TMPRSS2 acts as a functional receptor for SARS coronavirus as well as for the new highly pathogenic coronavirus, 2019-nCoV/SARS-CoV-2, which is cause for pneumonia COVID-19.
Keywords: Ace2, EC=3.4.17.23, SARS-Receptor, Angiotensin-converting Enzyme 2, ACEH, Metalloprotease MPROT15, SARS-CoV-2-Receptor
Supplier: AdipoGen Life Sciences
Supplier-Nr: AG-40B-0193

Properties

Conjugate: No
Host: Human cells
Species reactivity: mouse
MW: ~100 kD
Purity: >=95% (SDS-PAGE)
Format: Lyophilized

Handling & Safety

Storage: -20°C (avoid repeat freezing and thawing cycles)
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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