Suc-Leu-Leu-Val-Tyr-AMC (trifluoroacetate salt)

Suc-Leu-Leu-Val-Tyr-AMC is a fluorogenic substrate for the 20S proteasome, other chymotrypsin-like proteases, and calpains. Upon enzymatic cleavage, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify protease activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.Formal Name: N-(3-carboxy-1-oxopropyl)-L-leucyl-L-leucyl-L-valyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-tyrosinamide, trifluoroacetate salt. Synonyms: Suc-LLVY-AMC. Molecular Formula: C40H53N5O10 . XCF3COOH. Formula Weight: 763.9. Purity: >98%. Emission: 440-460 nm. Excitation: 340-360 nm. Formulation: (Request formulation change), A solid. Solubility: DMF: 2 mg/ml, DMSO: 3 mg/ml. lambdamax: 324 nm. SMILES: CC(C1=CC=C(C=C1O2)NC([C@H](CC3=CC=C(C=C3)O)NC([C@@H](NC([C@@H](NC([C@@H](NC(CCC(O)=O)=O)CC(C)C)=O)CC(C)C)=O)C(C)C)=O)=O)=CC2=O.FC(F)(F)C(O)=O. InChi Code: InChI=1S/C40H53N5O10.C2HF3O2/c1-21(2)16-29(42-33(47)14-15-34(48)49)38(52)43-30(17-22(3)4)39(53)45-36(23(5)6)40(54)44-31(19-25-8-11-27(46)12-9-25)37(51)41-26-10-13-28-24(7)18-35(50)55-32(28)20-26,3-2(4,5)1(6)7/h8-13,18,20-23,29-31,36,46H,14-17,19H2,1-7H3,(H,41,51)(H,42,47)(H,43,52)(H,44,54)(H,45,53)(H,48,49),(H,6,7)/t29-,30-,31-,36-,/m0./s1. InChi Key: DIIZONRJGINNAC-JJCSBACLSA-N.