87 products were found matching "K02737"!
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Lactacystin
Item number: Cay70980-100
Lactacystin is a microbial metabolite isolated from Streptomyces that is now widely used as a selective inhibitor of the 20S proteasome. Lactacystin was first characterized by its ability to induce differentiation and inhibit cell cycle progression in several tumor cell lines. At concentrations from 2 to 10 µM,...
| Keywords: | 3S-hydroxy-2R-(1-hydroxy-2-methylpropyl)-4R-methyl-5-oxo-2-pyrrolidinecarboxylate-N-acetyl-L-cysteine |
| Application: | 20S proteasome inhibitor |
| CAS | 133343-34-7 |
| MW: | 376.4 D |
From 49.00€
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Bortezomib
Item number: Cay10008822-5
Bortezomib is a dipeptide boronic acid derivative that reversibly inhibits the 20S proteasome (Ki = 0.6 nM). It binds the beta5-subunit of the 20S proteasome and selectively inhibits chymotryptic activity. In part by blocking the degradation of tumor-suppressing and proapoptotic proteins, bortezomib drives cell...
| Keywords: | LDP-341, MG-341, MLN341, NSC 681239, PS-341,... |
| Application: | Proteasome subunit beta type-1/5 inhibitor |
| CAS | 179324-69-7 |
| MW: | 384.2 D |
From 44.00€
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Ixazomib citrate
Item number: TGM-T8397-10mg
Description: Ixazomib citrate (MLN9708) is a prodrug of Ixazomib (MLN-2238) and an orally bioavailable second-generation proteasome inhibitor with an IC50 of 3.4 nM, exhibiting potential antineoplastic activity. Target: Proteasome, Autophagy. Smiles:...
| Keywords: | MLN9708 |
| Application: | Targets 20S proteasome subunit beta 5 [EC:3.4.25.1] (PSMB5) |
| CAS | 1239908-20-3 |
| MW: | 517.12 D |
From 43.00€
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Oprozomib
Item number: TGM-T6041-100mg
Description: Oprozomib (PR-047) (ONX 0912) , an inhibitor for CT-L activity of 20S proteasome beta5(IC50=36 nM)/LMP7(IC50=82 nM), is orally bioavailable. Oprozomib also has potential antineoplastic activity. Target: Proteasome, Autophagy. Smiles:...
| Keywords: | PR-047, ONX 0912 |
| Application: | Targets 20S proteasome subunit beta 5 [EC:3.4.25.1] (PSMB5) |
| CAS | 935888-69-0 |
| MW: | 532.61 D |
From 58.00€
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Epoxomicin
Item number: TGM-T6830-100mg
Description: Epoxomicin (BU-4061T,Aids010837) is a selective proteasome inhibitor with anti-inflammatory activity, inhibits primarily the CH-L activity of the 20S proteasome, while T-L and PGPH catalytic activities are also inhibited at 100- and 1000-fold reduced rate. Target: Apoptosis, Proteasome. Smiles:...
| Keywords: | BU-4061T, BU-4061T,Aids010837 |
| Application: | Antibiotic, anticancer compound, Cell-permeable irreversible 20S proteasome inhibitor |
| CAS | 134381-21-8 |
| MW: | 554.72 D |
From 126.00€
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PI-1840
Item number: TGM-T6941-100mg
Description: PI-1840(IC50 = 27 nM)is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like (PGPH-L). Target: PARP, Proteasome. Smiles: CCCc1ccc(OCC(=O)N(Cc2nc(no2)-c2cccnc2)C(C)C)cc1. References: Ozcan...
| Keywords: | PI 1840 |
| Application: | Proteasome inhibitor |
| CAS | 1401223-22-0 |
| MW: | 394.47 D |
From 33.00€
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Suc-Leu-Leu-Val-Tyr-AMC
Item number: TGM-TP1308-10mg
Description: Suc-Leu-Leu-Val-Tyr-AMC is a fluorescent substrate for the 20S proteasome, as well as other chymotrypsin-like proteases (20S-proteasome/chymotrypsin). Smiles: CC(C)C[C@H](NC(=O)CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)Nc1ccc2c(C)cc(=O)oc2c1. References: Roberta L....
| Application: | Fluorogenic proteasome substrate |
| CAS | 94367-21-2 |
| MW: | 763.88 D |
From 84.00€
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Carfilzomib
Item number: TGM-T1795-100mg
Description: Carfilzomib (PR-171) is a proteasome inhibitor that irreversibly binds to the chymotrypsin of the 20S proteasome. Carfilzomib has antitumor activity and may be used to treat multiple myeloma. Target: Proteasome, Autophagy, Apoptosis. Smiles:...
| Keywords: | PR-171 |
| Application: | Targets 20S proteasome subunit beta 5 [EC:3.4.25.1] (PSMB5) |
| CAS | 868540-17-4 |
| MW: | 719.91 D |
From 48.00€
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![PS-341 [Bortezomib]](https://www.biomol.com/media/image/e7/b4/85/AG-CR1-3602-M005_200x200.png "PS-341 [Bortezomib]")
PS-341 [Bortezomib]
Item number: AG-CR1-3602-M005
White solid. Soluble in DMSO, ethanol or methanol. Slightly soluble in water. Highly potent, selective and reversible cell permeable inhibitor of the proteasome. Inhibits the chymotrypsin-like and caspase-like peptidase activity of the proteasome, Calpain and cathepsin inhibitor, Autophagy activator, Anticancer...
| Keywords: | PS-341, LDP-341, MLM-341, MG-341, NSC-681239, Proteasome Inhibitor |
| Application: | Highly potent selective, reversible, cell permeable proteasome inhibitor |
| CAS | 179324-69-7 |
| MW: | 384,2 D |
From 61.00€
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Clasto-Lactacystin beta-lactone
Item number: Cay70988-100
Lactacystin is a microbial metabolite isolated from Streptomyces that is now widely used as a selective inhibitor of the 20S proteasome. Clasto-lactacystin beta-lactone was later identified as the active metabolite of lactacystin, resulting from the elimination of cysteine and the formation of a reactive...
| Keywords: | 1R-(1S-1hydroxy-2-methylpropyl)-4R-methyl-6-oxa-2-azabicyclo(320)heptane-3,7-dione |
| Application: | Proteasome inhibitor |
| CAS | 154226-60-5 |
| MW: | 213.2 D |
From 96.00€
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K-7174 dihydrochloride
Item number: TGM-T11742L-10mg
Description: K-7174 dihydrochloride is a proteasome and GATA inhibitor that inhibits neuronal degeneration and induces apoptosis. Target: Proteasome. Smiles: Cl.Cl.COc1cc(\C=C\CCCN2CCCN(CCC\C=C\c3cc(OC)c(OC)c(OC)c3)CC2)cc(OC)c1OC. References: Umetani M, et al. A novel cell adhesion inhibitor, K-7174, reduces the...
| Keywords: | K7174 2HCl, K-7174 2HCl, K 7174 2HCl |
| Application: | 20S proteasome inhibitor |
| CAS | 191089-60-8 |
| MW: | 641.67 D |
From 31.00€
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Lactacystin
Item number: TGM-T15702-1mg
Description: Lactacystin is an antibiotic Streptomyces spp. the metabolite and is an effective and selective proteasome inhibitor (IC50: 4.8 µM for 20S proteasome). Lactacystin inhibits cell growth and induces neurite outgrowth and also inhibits the lysosomal enzyme cathepsin A. Target: Proteasome. Smiles:...
| Application: | Irreversible proteasome inhibitor |
| CAS | 133343-34-7 |
| MW: | 376.43 D |
From 88.00€
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