PKCzeta Pseudosubstrate Inhibitor

The atypical protein kinase C isoform, PKCzeta, is critical for mediating mitogenic signal transduction, cell survival, and some of the physiological actions of insulin. PKCzeta pseudosubstrate inhibitor is a synthetic peptide that corresponds to a pseudosubstrate domain of this PKC isoform. It selectively, reversibly, and substrate-competitively inhibits PKCzeta activity and, thus, is used to delineate the signaling functions of PKCzeta.Formal Name: L-seryl-L-isoleucyl-L-tyrosyl-L-arginyl-L-arginylglycyl-L-alanyl-L-arginyl-L-arginyl-L-tryptophyl-L-arginyl-L-lysyl-L-leucine. CAS Number: 799764-07-1. Synonyms: Protein Kinase Czeta Pseudosubstrate Inhibitor. Molecular Formula: C76H128N30O16. Formula Weight: 1718.0. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: [H]N[C@@H](CO)C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)CC1=CNC2=C1C=CC=C2)=O)=O)=O. InChi Code: InChI=1S/C76H128N30O16/c1-6-41(4)59(106-61(111)47(78)39-107)70(120)104-55(35-43-24-26-45(108)27-25-43)68(118)101-52(21-13-31-91-74(83)84)64(114)98-49(19-11-29-89-72(79)80)62(112)95-38-58(109)96-42(5)60(110)97-51(20-12-30-90-73(81)82)63(113)100-54(23-. InChi Key: ISDDDWMHYBTNSA-RRIFIRBXSA-N.