61 products were found matching "K18952"!

Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent...

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. Pan-PKC antibody detects protein kinase C isoforms alpha, beta, and zeta, encoded by the PRKCA, PRKCB, and PRKCZ genes. PKC proteins are a family of serine/threonine kinases activated by...

The atypical protein kinase C isoform, PKCzeta, is critical for mediating mitogenic signal transduction, cell survival, and some of the physiological actions of insulin. PKCzeta pseudosubstrate inhibitor is a synthetic peptide that corresponds to a pseudosubstrate domain of this PKC isoform. It selectively,...

Protein function: Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory...

Protein function: Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory...

This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. Phosphorylates 'Ser-311' of RELA subunit of NF-kappa-B.PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor...

PKC-9 is an inhibitor of PKCzeta that is 8,000-, 20,671-, 711-, 918-, 1,895-, 12,424-, 10-, and 1,218-fold selective for PKCzeta over PKCalpha, PKCbetaII, PKCgamma, PKCdelta, PKCepsilon, PKCeta, PKCiota, and PKCtheta, respectively. It also inhibits 27 additional kinases in a panel of 37 kinases when used at a...

Protein function: Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory...

CRT0066854 is an inhibitor of PKCiota and PKCzeta (IC50s = 132 and 639 nM, respectively). It also inhibits the Rho-associated kinase II (ROCK2) kinase domain (IC50 = 620 nM). It is selective for these atypical PKCs and ROCK2 over typical PKCs and 98 other kinases in a panel at 1 µM. CRT0066854 decreases...

Myr-ZIP is a cell-permeable inhibitor of the constitutively active protein kinase C (PKC) isoform PKMzeta (Ki = 0.076-2.11 µM). It also inhibits PKCalpha when used at a concentration of 10 µM. Myr-ZIP (5 µM) prevents PKC translocation to the plasma membrane induced by ionomycin (Cay-10004974, Cay-11932) in HEK293...

Protein function: Calcium- and diacylglycerol-independent serine/threonine- protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PKCz. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PKCz. Next,...