Pepstatin A

White to off-white powder. Soluble in DMSO, methanol or acetic acid. Tight-binding, reversible, highly selective inhibitor of acid proteases (aspartyl peptidases), like pepsin, gastricsin, cathepsin E and D, renin, chymosin, bacterial aspartic proteinases and HIV proteases, Does not inhibit thiol proteases, neutral proteases or serine proteases, Widely used as a research tool in studies of protease mechanisms and biological functions, Solubilized gamma-secretase and retroviral protease inhibitor, Shows antibacterial, antifungal and antiparasitic activity, Suppresses p53-dependent apoptosis in lymphoid cells as well as TNFalpha-induced apoptosis in U937 cells, Inhibits degradation of autophagic cargo inside autophagolysosomes.