An inhibitor of acid proteases isolated from streptomyces. It has been shown to induce contractile effects on rat aorta rings.

Purity: >98% (HPLC). Rev. inhibitor of aspartic proteinases, e.g. cathepsin D, renin, pepsin, bacterial aspartic proteinases and HIV protease. Soluble in MeOH or EtOH at 1 mg/ml, stable for 1 week at 4 °C. Eff. conc.: 1-5 µM.

Pepstatin A is a bacteria-derived pentapeptide inhibitor of aspartic proteases. It inhibits pepsin, cathepsin D, and HIV protease (IC50s = 50s = 0.32 and 15 µM for the porcine and human enzymes, respectively). It inhibits HIV replication in infected H9 cells when used at a concentration of 100 µM and inhibits...

Pepstatin A is used as a protease inhibitor. Pepstatin forming a 1:1 complex with the carboxylproteases (acid proteases) bovine chymosin, cathepsin D, pepsin, protease B and renin. The inhibitor is highly selective and does not inhibit thiol proteases, neutral proteases or serine proteases. Solublized...

White to off-white powder. Soluble in DMSO, methanol or acetic acid. Tight-binding, reversible, highly selective inhibitor of acid proteases (aspartyl peptidases), like pepsin, gastricsin, cathepsin E and D, renin, chymosin, bacterial aspartic proteinases and HIV proteases, Does not inhibit thiol proteases, neutral...