WKYMVm (trifluoroacetate salt)

WKYMVm is a synthetic peptide agonist of formyl peptide receptor 1 (FPR1) and FPR2, which was previously known as formyl peptide receptor-like 1 (FPRL1). It induces calcium mobilization in ETFR rat basophilic leukemia cells transfected with FPR1 or FPR2 when used at a concentration of 0.1 nM. WKYMVm stimulates chemotaxis of monocytes, dendritic cells, and natural killer (NK) cells, as well as induces superoxide production in monocytes and neutrophils, in vitro. In vivo, WKYMVm (8 mg/kg) reverses mucosal destruction, decreases in body weight, and colonic shortening in a mouse model of colitis induced by dextran sulfate (sodium salt) (DSS, Cay-23250). Topical application of WKYMVm stimulates angiogenesis and accelerates re-epithelialization and granulation tissue formation in a rat model of diabetic cutaneous wounds.Formal Name: L-tryptophyl-L-lysyl-L-tyrosyl-L-methionyl-L-valyl-D-methioninamide, trifluoroacetate salt. Synonyms: Trp-Lys-Tyr-Met-Val-D-Met. Molecular Formula: C41H61N9O7S2 . XCF3COOH. Formula Weight: 856.1. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:4): 0.20 mg/ml. lambdamax: 219 nm. SMILES: OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](CCSC)C(N[C@@H](C(C)C)C(N[C@@H](C(N)=O)CCSC)=O)=O)=O)NC([C@H](CCCCN)NC([C@@H](N)CC2=CNC3=CC=CC=C23)=O)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C41H61N9O7S2.C2HF3O2/c1-24(2)35(41(57)46-31(36(44)52)16-19-58-3)50-39(55)33(17-20-59-4)48-40(56)34(21-25-12-14-27(51)15-13-25)49-38(54)32(11-7-8-18-42)47-37(53)29(43)22-26-23-45-30-10-6-5-9-28(26)30,3-2(4,5)1(6)7/h5-6,9-10,12-15,23-24,29,31-35,45,51H,7-8,11,16-22,42-43H2,1-4H3,(H2,44,52)(H,46,57)(H,47,53)(H,48,56)(H,49,54)(H,50,55),(H,6,7)/t29-,31+,32-,33-,34-,35-,/m0./s1. InChi Key: MYVYQWVNXDVTBW-HQORXVKSSA-N.