PTD2 (trifluoroacetate salt)

PTD2 is a peptide inhibitor of the histone methyltransferase Wolf-Hirschhorn syndrome candidate 1 (WHSC1, IC50 = 22 µM) that was derived from the histone 4 sequence.Formal Name: (S)-2-(2-((5S,8S)-8-(2-acetamidoacetamido)-9-methyl-6,7-dioxodecan-5-yl)hydrazineyl)-N-((2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl)-5-guanidinopentanamide, trifluoroacetate salt. Molecular Formula: C27H51N9O6 . XCF3COOH. Formula Weight: 597.8. Purity: >98%. Formulation: (Request formulation change), A solid. Peptide Sequence: Ac-GV[Nle]RI-NH2. Solubility: DMF: 2 mg/ml, DMSO: 10 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: NC([C@@]([C@H](CC)C)([H])NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](C(C)C)NC(CNC(C)=O)=O)=O)CCCC)=O)=O)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C27H51N9O6.C2HF3O2/c1-7-9-11-18(34-26(42)21(15(3)4)35-20(38)14-32-17(6)37)24(40)33-19(12-10-13-31-27(29)30)25(41)36-22(23(28)39)16(5)8-2,3-2(4,5)1(6)7/h15-16,18-19,21-22H,7-14H2,1-6H3,(H2,28,39)(H,32,37)(H,33,40)(H,34,42)(H,35,38)(H,36,41)(H4,29,30,31),(H,6,7)/t16-,18-,19-,21-,22-,/m0./s1. InChi Key: BWPZGRSRSLFIKA-CMYPUELESA-N.