17 products were found matching "K11424"!
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UNC7145
Item number: Cay40166-1
UNC7145 is an inactive derivative of the histone-lysine N-methyltransferase NSD2 inhibitor UNC6934 that has been used as a negative control for the histone methyltransferase activity of NSD2.Formal Name:...
| Keywords: | 3,4-dihydro-N-(1-methylethyl)-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]-2H-1,4-benzoxazine-7-carboxamide |
| Application: | Inactive UNC6934 derivative, negative control |
| CAS | 2561494-78-6 |
| MW: | 445.5 D |
From 38.00€
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PTD2 (trifluoroacetate salt)
Item number: Cay38842-1
PTD2 is a peptide inhibitor of the histone methyltransferase Wolf-Hirschhorn syndrome candidate 1 (WHSC1, IC50 = 22 µM) that was derived from the histone 4 sequence.Formal Name:...
| Keywords: | (S)-2-(2-((5S,8S)-8-(2-acetamidoacetamido)-9-methyl-6,7-dioxodecan-5-yl)hydrazineyl)-N-((2S,3S)-1-amino-3-methyl-1-oxopent... |
| Application: | WHSC1 peptide inhibitor |
| MW: | 597.8 D |
From 68.00€
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UNC8153 (trifluoroacetate salt)
Item number: Cay38932-1
UNC8153 is a degrader of the histone-lysine N-methyltransferase NSD2. It induces its degradation of NSD2 with a 50% degradation constant (DC50) value of 350 nM and is selective for NSD2 over NSD1 and NSD3 at 20 µM. UNC8153 (10 µM) induces NSD2 degradation and reduces histone H3 lysine 36 dimethylation (H3K36me2) in...
| Keywords: | N-[[4-[[[4-[[(6-aminohexyl)amino]carbonyl]phenyl]amino]carbonyl]phenyl]methyl]-N-cyclopropyl-3,4-dihydro-3-oxo-2H-1,4-benz... |
| Application: | NSD2 degrader |
| CAS | 2929304-61-8 |
| MW: | 697.7 D |
From 96.00€
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Anti-NSD2
Item number: A303-093A
Protein function: Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Isoform 2 may act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment. [The UniProt Consortium]
| Keywords: | Anti-NSD2, Anti-WHSC1, Anti-MMSET, Anti-KIAA1090, EC=2.1.1.43, Anti-Protein trithorax-5, Anti-Histone-lysine... |
| Application: | WB, IP |
| Host: | Rabbit |
| Species reactivity: | human |
From 164.00€
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NSD2 (catalytic domain), active human recombinant protein
Item number: BPS-51026
Active human NSD2 (MMSET) (GenBank Accession No. NM_133330), amino-acids 941-1240 with N-terminal GST tag, MW = 62 kDa, expressed in E. coli.
| Keywords: | MMSET, KIAA1090, Protein trithorax-5, Nuclear SET domain-containing protein 2, Histone-lysine N-methyltransferase NSD2,... |
| Application: | Enzyme kinetics, inhibitor screening |
| MW: | 62 kD |
664.00€
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NSD2 Chemiluminescent Assay Kit
Item number: BPS-79359
The NSD2 Chemiluminescent Assay Kit is designed to measure NSD2 activity for screening and profiling applications. The key to the NSD2 Chemiluminescent Activity Assay Kit is a highly specific antibody that recognizes methylated residue of Histone H3. With this kit, only three simple steps are required for...
| Keywords: | WHSC1, Wolf-Hirschhorn Syndrome Candidate 1, MMSET, Multiple Myeloma SET Domain Containing Protein, NSD2, Nuclear SET... |
| Application: | Enzyme kinetics, HTS |
| Species reactivity: | human |
1,603.00€
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Anti-WHSC1
Item number: E-AB-62262.120
This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of...
| Keywords: | Anti-MMSET, Anti-KIAA1090, EC=2.1.1.43, Anti-Protein trithorax-5, Anti-Histone-lysine N-methyltransferase NSD2,... |
| Application: | WB, IHC |
| Host: | Rabbit |
| Species reactivity: | human, mouse |
From 198.00€
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Anti-WHSC1
Item number: G-CAB7938.100
| Application: | IHC, WB |
| Host: | Rabbit |
| Species reactivity: | human, mouse |
From 352.00€
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Anti-NSD2, clone CL1057
Item number: ATA-AMAb90848.100
Protein function: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:27571355, PubMed:22099308, PubMed:19808676, PubMed:29728617). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate...
| Keywords: | Anti-MMSET, Anti-KIAA1090, Anti-Protein trithorax-5, Anti-Histone-lysine N-methyltransferase NSD2, Anti-Nuclear SET... |
| Application: | ICC, IHC |
| Host: | Mouse |
| Species reactivity: | human |
From 335.00€
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Anti-NSD2, clone CL1063
Item number: ATA-AMAb90851.100
Protein function: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:27571355, PubMed:22099308, PubMed:19808676, PubMed:29728617). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate...
| Keywords: | Anti-MMSET, Anti-KIAA1090, Anti-Protein trithorax-5, Anti-Histone-lysine N-methyltransferase NSD2, Anti-Nuclear SET... |
| Application: | ICC, IHC, WB |
| Host: | Mouse |
| Species reactivity: | human |
From 300.00€
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Anti-NSD2
Item number: ATA-HPA015801.100
Protein function: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:27571355, PubMed:22099308, PubMed:19808676, PubMed:29728617). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate...
| Keywords: | Anti-MMSET, Anti-KIAA1090, Anti-Protein trithorax-5, Anti-Histone-lysine N-methyltransferase NSD2, Anti-Nuclear SET... |
| Application: | ICC, IHC |
| Host: | Rabbit |
| Species reactivity: | human |
From 335.00€
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NSD2 Chemiluminescent Assay Kit
Item number: BPS-53009
The NSD2 Chemiluminescent Assay Kit is designed to measure NSD2 activity for screening and profiling applications. The NSD2 Chemiluminescent Assay Kit comes in a convenient format, with 96-well plate precoated with histone H3 substrate, the antibody against methylated lysine residue of Histone H3, a secondary...
| Keywords: | WHSC1, Wolf-Hirschhorn Syndrome Candidate 1, MMSET, Multiple Myeloma SET Domain Containing Protein, NSD2, Nuclear SET... |
| Application: | Enzyme kinetics, HTS |
| Species reactivity: | human |
1,101.00€
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