PAR1 (1-6) (mouse, rat) (trifluoroacetate salt)

PAR1 (1-6) (mouse, rat) (trifluoroacetate salt)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay27111-500 500 µg -

6 - 10 business days*

158.00€
Cay27111-1 1 mg -

6 - 10 business days*

294.00€
 
PAR1 (1-6) is a hexapeptide that corresponds to amino acid residues 1-6 of the amino terminal... more
Product information "PAR1 (1-6) (mouse, rat) (trifluoroacetate salt)"
PAR1 (1-6) is a hexapeptide that corresponds to amino acid residues 1-6 of the amino terminal tethered ligand sequence of mouse and rat proteinase-activated receptor 1 (PAR1), residues 42-47 of the full-length mouse sequence, and residues 46-51 of the full-length rat sequence. PAR1 is a high-affinity thrombin receptor that induces platelet activation and deposition into thrombi as well as smooth muscle mitogenesis. Unlike thrombin, PAR1 (1-6) acts as an agonist of PAR1 in smooth muscle cells but is inactive in rodent platelets. It increases mitogenesis and the expression of the IGF-1 receptor (IGF-1R) by 47% in vascular smooth muscle cells (VSMCs), an effect that is inhibited by the thrombin inhibitor hirudin and by the protein tyrosine kinase inhibitor genistein (Cay-10005167). PAR1 (1-6) increases histamine and beta-hexosaminidase release from rat peritoneal mast cells in a concentration-dependent manner, with the maximum release at a concentration of 50 µM. It also mimics the effect of thrombin, increasing swelling-activated efflux of [3H]glutamate induced by hypoosmotic medium in astrocytes in vitro when used at concentrations ranging from 5 to 10 µM.Formal Name: L-seryl-L-phenylalanyl-L-phenylalanyl-L-leucyl-L-arginyl-L-asparagine, trifluoroacetate salt. Synonyms: H-Ser-Phe-Phe-Leu-Arg-Asn, PAR1-AP, Proteinase-Activated Receptor 1, SFFLRN, TRAP, Thrombin Receptor Activating Peptide. Molecular Formula: C37H54N10O9 . XCF3COOH. Formula Weight: 782.9. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Water: 1 mg/ml. SMILES: [H]N[C@@H](CO)C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(O)=O)=O)=O)=O)CC1=CC=CC=C1)=O)CC2=CC=CC=C2)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C37H54N10O9.C2HF3O2/c1-21(2)16-26(33(52)43-25(14-9-15-42-37(40)41)32(51)47-29(36(55)56)19-30(39)49)45-35(54)28(18-23-12-7-4-8-13-23)46-34(53)27(44-31(50)24(38)20-48)17-22-10-5-3-6-11-22,3-2(4,5)1(6)7/h3-8,10-13,21,24-29,48H,9,14-20,38H2,1-2H3,(H2,39,49)(H,43,52)(H,44,50)(H,45,54)(H,46,53)(H,47,51)(H,55,56)(H4,40,41,42),(H,6,7)/t24-,25-,26-,27-,28-,29-,/m0./s1. InChi Key: NTVASBVJSJIDKA-IGCYJKAMSA-N.
Keywords: H-Ser-Phe-Phe-Leu-Arg-Asn, PAR1-AP, Proteinase-Activated Receptor 1, SFFLRN, Thrombin Receptor Activating Peptide, TRAP, L-seryl-L-phenylalanyl-L-phenylalanyl-L-leucyl-L-arginyl-L-asparagine, trifluoroacetate salt
Supplier: Cayman Chemical
Supplier-Nr: 27111

Properties

Application: PAR1 agonist
Conjugate: No
MW: 782.9 D
Formula: C37H54N10O9 . XCF3COOH
Purity: >95%
Format: Solid

Database Information

KEGG ID : K03914 | Matching products
UniProt ID : P25116 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "PAR1 (1-6) (mouse, rat) (trifluoroacetate salt)"
Write a review
or to review a product.
Viewed