44 products were found matching "K03914"!

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PAR1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PAR1. Next,...

TRAP-6 peptide is a hexapeptide corresponding to residues 42-47 of protease-activated receptor 1 (PAR1). It acts as an agonist of PAR1, inducing platelet aggregation in human platelet-rich plasma ex vivo (EC50 = 0.8 µM). TRAP-6 (0.3 and 0.6 mg/kg) has a triphasic effect on mean arterial blood pressure (MAP) in...

Vorapaxar is an orally bioavailable competitive antagonist of the proteinase-activated receptor (PAR1, Ki = 8.1 nM), also known as the thrombin receptor. It is selective for PAR1 over other PARs, as well as a number of GPCRs, ion channels, and receptors. It inhibits platelet aggregation induced by thrombin...

TFLLR-NH2 is a synthetic peptide agonist of proteinase-activated receptor 1 (PAR1) that induces calcium mobilization in isolated rat dorsal root ganglion neurons (EC50 = 1.9 µM). In vivo, TFLLR-NH2 (3 µmol/kg) stimulates plasma extravasation in the bladder, esophagus, stomach, intestine, and pancreas in wild-type,...

TRAP-6 amide is a peptide agonist of proteinase-activated receptor 1 (PAR1). It induces platelet aggregation in vitro (EC50 = 0.15 µM). TRAP-6 amide (30 µM) induces relaxation of isolated guinea pig internal anal sphincter strips. It also increases cigarette smoke extract-induced IL-8 release from isolated human...

Protein function: High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development. [The UniProt Consortium]

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Proteinase-activated receptor 1 (PAR-1), also known as the coagulation factor II (thrombin) receptor, is a protein that in humans is encoded by the F2R gene. By fluorescence in situ hybridization, this gene is mapped to 5q13, confirming its presence as a single...

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Protease-activated receptor 1 antibody, thrombin receptor, TR, F2R, coagulation factor II (thrombin) receptor Protein function: High affinity receptor for activated thrombin coupled to G...

Allosteric and reversible inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50 = 0.26 µM for the inhibition of platelet P-selectin expression on human platelets).

Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. High affinity receptor for activated thrombin coupled to G proteins that stimulate...