Neuromedin C (trifluoroacetate salt)

Neuromedin C (trifluoroacetate salt)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay24706-1 1 mg -

6 - 10 business days*

135.00€
 
Neuromedin C is a bombesin-like neuropeptide that stimulates uterine smooth muscle contraction... more
Product information "Neuromedin C (trifluoroacetate salt)"
Neuromedin C is a bombesin-like neuropeptide that stimulates uterine smooth muscle contraction and the release of gastrin (Cay-24457), somatostatin, and amylase in rats. Neuromedin C is a truncated form of gastrin-releasing peptide (GRP, Cay-24415, Cay-24455) corresponding to the GRP amino acids 18-27. It inhibits GRP and bombesin (Cay-24151) binding to rat pancreatic membranes (IC50s = 0.4 and 2.2 nM, respectively), which can be reduced by sodium chloride and guanylyl imidodiphosphate (Cay-16880). Neuromedin C induces scratching and mast cell degranulation in mice when administered intradermally at doses ranging from 1 to 300 nmol/site, which is inhibited by the BB2 bombesin receptor agonist RC-3095 and reduced in mast cell-deficient mice. Neuromedin C (3.2 nmol/kg, i.p.) reduces rat glucose consumption by approximately 50% for up to one hour.Formal Name: 7-L-histidine-5-14-bombesin. Synonyms: GRP(18-27), NMC. Molecular Formula: C50H73N17O11S . XCF3COOH. Formula Weight: 1120.3. Purity: >95%. Formulation: (Request formulation change), A lyophilized powder. Solubility: Water: 1 mg/ml. SMILES: NC([C@@H](NC([C@H](CC(C)C)NC([C@@H](NC(CNC([C@H](C(C)C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC(N)=O)NC(CN[H])=O)=O)CC1=CN=CN1)=O)CC2=CNC3=C2C=CC=C3)=O)C)=O)=O)=O)CC4=CN=CN4)=O)=O)CCSC)=O.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C50H73N17O11S.C2HF3O2/c1-25(2)13-34(46(74)63-33(43(53)71)11-12-79-6)64-47(75)36(15-29-20-54-23-58-29)62-41(70)22-57-50(78)42(26(3)4)67-44(72)27(5)60-45(73)35(14-28-19-56-32-10-8-7-9-31(28)32)65-48(76)37(16-30-21-55-24-59-30)66-49(77)38(17-39(52)68)61-40(69)18-51,3-2(4,5)1(6)7/h7-10,19-21,23-27,33-38,42,56H,11-18,22,51H2,1-6H3,(H2,52,68)(H2,53,71)(H,54,58)(H,55,59)(H,57,78)(H,60,73)(H,61,69)(H,62,70)(H,63,74)(H,64,75)(H,65,76)(H,66,77)(H,67,72),(H,6,7)/t27-,33-,34-,35-,36-,37-,38-,42-,/m0./s1. InChi Key: YTDVZQVYMKGASO-PQMUPELQSA-N.
Keywords: GRP(18-27), 7-L-histidine-5-14-bombesin
Supplier: Cayman Chemical
Supplier-Nr: 24706

Properties

Application: Neuropeptide
Conjugate: No
MW: 1120.3 D
Formula: C50H73N17O11S . XCF3COOH
Purity: >95%
Format: Solid

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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