Myr-Tat-CBD3 (trifluoroacetate salt)

Myr-Tat-CBD3 is an inhibitor of the protein-protein interaction between the N-type voltage-gated calcium channel Cav2.2 and collapsin response mediator protein 2 (CRMP2). It inhibits the Cav2.2-CRMP2 interaction by approximately 81% when used at a concentration of 10 µM and inhibits potassium-induced calcium influx in primary rat dorsal root ganglion (DRG) neurons (IC50 = ~2.8 µM). Myr-Tat-CBD3 (20 µM) inhibits calcium, but not sodium, currents in primary DRG neurons. Intrathecal administration of myr-Tat-CBD3 (20 µg/5 µl) prevents carrageenan-induced decreases in paw withdrawal latencies in rats. Myr-Tat-CBD3 decreases cue-induced reinstatement of cocaine-seeking behavior in rats.Formal Name: N-myristoyl-L-tyrosylglycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-alanyl-L-arginyl-L-seryl-L-arginyl-L-leucyl-L-alanyl-L-alpha-glutamyl-L-leucyl-L-arginylglycyl-L-valyl-L-prolyl-L-arginylglycyl-L-leucine, trifluoroacetate salt. Synonyms: N-myristate-Tat-CBD3, Myr-Tat-Calcium Channel-binding Domain 3. Molecular Formula: C148H269N59O33 . XCF3COOH. Formula Weight: 3403.1. Purity: >95%. Formulation: (Request formulation change), A solid. Peptide Sequence: myristoyl-YGRKKRRQRRRARSRLAELRGVPRGL-OH. Solubility: Water: Soluble. SMILES: OC(C(F)(F)F)=O.CCCCCCCCCCCCCC(N[C@@H](CC1=CC=C(O)C=C1)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](C(C)C)C(N2CCC[C@H]2C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@H](C(O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)=O)C)=O)CC(C)C)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O. InChi Code: InChI=1S/C148H269N59O33.C2HF3O2/c1-12-13-14-15-16-17-18-19-20-21-22-51-110(211)188-105(76-87-52-54-88(209)55-53-87)120(221)184-77-111(212)187-91(42-29-64-174-141(156)157)122(223)193-92(38-23-25-60-149)123(224)194-93(39-24-26-61-150)124(225)196-97(46-33-68-178-145(164)165)126(227)198-99(48-35-70-180-147(168)169)128(229)201-101(56-58-109(151)210)131(232)199-98(47-34-69-179-146(166)167)127(228)197-96(45-32-67-177-144(162)163)125(226)195-94(43-30-65-175-142(158)159)121(222)185-85(10)116(217)190-95(44-31-66-176-143(160)161)130(231)205-107(80-208)135(236)200-100(49-36-71-181-148(170)171)129(230)203-103(73-81(2)3)133(234)186-86(11)117(218)191-102(57-59-114(215)216)132(233)204-104(74-82(4)5)134(235)192-89(40-27-62-172-139(152)153)118(219)183-79-113(214)206-115(84(8)9)137(238)207-72-37-50-108(207)136(237)202-90(41-28-63-173-140(154)155)119(220)182-78-112(213)189-106(138(239)240)75-83(6)7,3-2(4,5)1(6)7/h52-55,81-86,89-108,115,208-209H,12-51,56-80,149-150H2,1-11H3,(H2,151,210)(H,182,220)(H,183,219)(H,184,221)(H,185,222)(H,186,234)(H,187,212)(H,188,211)(H,189,213)(H,190,217)(H,191,218)(H,192,235)(H,193,223)(H,194,224)(H,195,226)(H,196,225)(H,197,228)(H,198,227)(H,199,232)(H,200,236)(H,201,229)(H,202,237)(H,203,230)(H,204,233)(H,205,231)(H,206,214)(H,215,216)(H,239,240)(H4,152,153,172)(H4,154,155,173)(H4,156,157,174)(H4,158,159,175)(H4,160,161,176)(H4,162,163,177)(H4,164,165,178)(H4,166,167,179)(H4,168,169,180)(H4,170,171,181),(H,6,7)/t85-,86-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,115-,/m0./s1. InChi Key: XNWNMTKREBTRTN-NHAGQNHRSA-N.